Cefpodoxime |
Last updated: 07/01/2024 |
(Also known as: Simplcef) |
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Cefpodoxime is an oral, third-generation cephalosporin antibiotic active against most gram-positive and gram-negative organisms. | |
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Used to treat infections of the respiratory and urinary tracts | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₁₅H₁₇N₅O₆S₂ | |
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COCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)O | |
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COCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)O | |
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WYUSVOMTXWRGEK-HBWVYFAYSA-N | |
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InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1 | |
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General status |
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Medicinal prodrug: antibiotic | |
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Cephalosporin | |
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Synthetic | |
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Acts by interfering with the formation of the bacteria's cell wall so that the wall ruptures, resulting in bacterial death | |
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[Peptidoglycan synthase FtsI, Inhibitor] | |
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82619-04-3 | |
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6335986 | |
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Other Beta-Lactam antibacterials: Third-generation cephalosporins | |
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QJ01DD13 | |
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427.46 | |
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(6R,7R)-7-(((2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl)amino)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid | |
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(6R,7R)-7-(((2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl)amino)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid | |
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Orange to red coloured solid |
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Proxetil | Pfizer | Not licensed | Not licensed | ||||||
Vantil | Pfizer | Not licensed | Not licensed | |||||||
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0.4 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
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cefpodoxime Note: Active metabolite |
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Terrestrial ecotoxicology |
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> 8000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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> 8000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LD₅₀ = 2535 mg kg⁻¹ | P3 P = Other non-EU, UK or US Governments and Regulators Mouse3 = Unverified data of known source |
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Subcutaneous LD₅₀ > 10000 mg kg⁻¹ | P3 P = Other non-EU, UK or US Governments and Regulators Mouse3 = Unverified data of known source |
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Absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Excreted rapidly in the urine (approx. 12 hrs) | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause mild gastro-intestinal problems including diarrhoea, nausia and vomiting May cause sensitisation via contact or inhalation |
Handling issues |
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No information available | |||
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Health: H317, H334 | |||
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Not listed (Not listed) | |||
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cefpodoxime | ||
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cefpodoxima | ||
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Record last updated: | 07/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |