Cyproheptadine hydrochloride (Ref: NSC 169911) |
Last updated: 21/05/2024 |
(Not known by any other names) |
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A broad-spectrum veterinary drug | |
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Current | |
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Multiple uses including (i) to treat dermatitis, (ii) as an appetite stimulant for sick animals, mainly cats, (iii) to treat feline asthma, (iv) to treat canine Cushing's Disease and (v) to treat behavioural problems in horses | |
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Cats; Dogs; Horses |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₂₁H₂₂NCl | |
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CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl | |
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No data | |
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ZPMVNZLARAEGHB-UHFFFAOYSA-N | |
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InChI=1S/C21H21N.ClH/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;/h2-11H,12-15H2,1H3;1H | |
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Common Name | Relationship | Link |
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cyproheptadine hydrochloride | Parent |
General status |
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Medicinal drug | |
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Unclassified substance | |
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Synthetic | |
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Serotonin and histamine antagonist | |
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[Histamine H1 receptor, Antagonist], [5-hydroxytryptamine receptor 2A, Antagonist], [5-hydroxytryptamine receptor 2C, Antagonist] | |
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969-33-5 | |
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213-535-1 | |
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Antihistamines for systemic use | |
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QR06AX02 | |
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No | |
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323.86 | |
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4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride | |
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4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride | |
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1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine hydrochloride | |
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White to yellowish coloured powder |
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112.3 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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93.3 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) (closed cup)3 = Unverified data of known source |
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4.90 X 1004 | Calculated | - | |||||||
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4.69 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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295 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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295 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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Intraperitoneal LD₅₀ = 55.3 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ = 23.0 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Hepatic metabolism with faecal excretion | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May have sedative effects Possible liver & blood toxicant May cause dizziness, confusion, disturbed coordination &/or restlessness May cause gastro-intestinal disturbances including nausea, vomiting & diarrhoea |
Handling issues |
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Will emit toxic gases when heated to decompostion Slightly flammable |
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Not listed (Not listed) | |||
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cyproheptadine hydrochloride | ||
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Record last updated: | 21/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |