Gabapentin |
Last updated: 21/05/2024 |
(Not known by any other names) |
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Gabapentin is an anticonvulsant drug used for both human and animal patients | |
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Current | |
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1993, introduced | |
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Once used to treat epilepsy and neuropathic pain but was also used to treat anxietym and fear associated with vet visits | |
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Cats; Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₉H₁₇NO₂ | |
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C1CCC(CC1)(CC(=O)O)CN | |
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No data | |
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UGJMXCAKCUNAIE-UHFFFAOYSA-N | |
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InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12) | |
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Yes |
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Common Name | Relationship | Link |
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gabapentin | - |
General status |
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Medicinal drug: Anticonvulsant & Pain Reliever | |
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Gamma amino-acid | |
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Synthetic | |
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Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels | |
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[Voltage-dependent calcium channel subunit alpha-2/delta-1, Inhibitor], [Voltage-dependent calcium channel subunit alpha-2/delta-2, Inhibitor], [Voltage-dependent N-type calcium channel subunit alpha-1B , Inhibitor], [Adenosine receptor A1 , Agonist], [NMDA receptor, Unknown action] | |
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60142-96-3 | |
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262-076-3 | |
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Antiepileptics: Other antiepileptics | |
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QN03AX12 | |
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UK: Class C, Schedule 3 | |
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171.24 | |
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1-(aminomethyl)cyclohexaneacetic acid | |
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1-(aminomethyl)cyclohexaneacetic acid | |
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1-(aminomethyl)cyclohexaneacetic acid | |
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White to off-white crystalline solid |
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Neurontin | Pfizer | Not licensed | Not licensed | ||||||
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4500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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162 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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7.94 X 10-02 | Calculated | - | |||||||
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-1.1 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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3.68 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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pKa(2)=10.70 | |||||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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> 8053 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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50 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio as mM4 = Verified data |
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General |
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> 8053 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Intravenous LD₅₀ > 1000 mg kg⁻¹ | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse3 = Unverified data of known source |
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Renal excretion as unchanged drug | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Health issues |
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May cause vomiting, drowsiness, loss of balance and/or diarrhoea May cause calcium, vitamin D, vitamin B1 & folate deficiencies |
Handling issues |
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Will emit toxic gases when heated to decomposition | |||
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Health: H315, H319, H360, H335 | |||
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Not listed (Not listed) | |||
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gabapentin | ||
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gabapentine | ||
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gabapentino | ||
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gabapentina | ||
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Record last updated: | 21/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |