Hydromorphone |
Last updated: 09/01/2024 |
(Also known as: dihydromorphinone) |
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A controlled veterinary drug, which is a morphine analogue usually used as the hydrochloride salt | |
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Current | |
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Used mainly as a sedative, restraining agent, analgesic or preanesthetic. | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₁₇H₁₉NO₃ | |
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CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4 | |
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CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4 | |
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WVLOADHCBXTIJK-YNHQPCIGSA-N | |
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InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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hydromorphone | - |
General status |
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Medicinal drug: analgesic | |
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Opoid | |
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Synthetic | |
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Acts by stimulating opiate receptors in CNS | |
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[Mu-type opioid receptor, Agonist], [Delta-type opioid receptor, Partial agonist], [Kappa-type opioid receptor, Agonist] | |
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466-99-9 | |
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207-383-5 | |
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Analgesics: Opiods | |
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QN02AA03; QN02AG04 | |
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UK: Class A, Schedule 2; EU: UN61/72, Class I | |
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285.34 | |
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(4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro(3,2-e)isoquinoline-7-one | |
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(4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro(3,2-e)isoquinoline-7-one | |
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4,5-epoxy-3-hydroxy-17-methylmorphinan-6-one | |
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White to slightly yellow crystalline solid |
Formulations |
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Dilaudid | Purdue Pharma, Canada | Not licensed | Not licensed | ||||||
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1931 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
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266 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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100 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.29 X 1000 | Calculated | - | |||||||
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0.11 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | V2 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 2 = Unverified data of unknown source |
Mobile | |||||||
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30 | ||||||||||
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Estimated | ||||||||||
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Fate indices |
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3.0 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low potential | |||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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Subcutaneous LD₅₀ = 84.0 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ = 104 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Metabolized in the liver as glucuronidated conjugate (major metabolite) and 6-hydroxy (minor metabolite) and excreted in the urine | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Health issues |
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CNS toxicant - may cause respiratory depression, sedation and bradycardia Skin & respiratory sensitiser |
Handling issues |
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When heated to decomposition it emits toxic fumes of nitroxides Closed containers may explode from the heat of fire |
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Helth: H317, H334; H336, H361 | |||
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Not listed (Not listed) | |||
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Not regulated | |||
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hydromorphone | ||
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hydromorfona | ||
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Record last updated: | 09/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |