Hydroxyzine |
Last updated: 09/01/2024 |
(Not known by any other names) |
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A veterinary antihistamine, often used as the hydrochloride or pamoate salt | |
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Current | |
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Used mainly to control skin allergies | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₂₁H₂₇ClN₂O₂ | |
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C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl | |
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No data | |
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ZQDWXGKKHFNSQK-UHFFFAOYSA-N | |
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InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2 | |
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Yes |
General status |
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Medicinal drug: antihistamine | |
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Piperazine | |
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Synthetic | |
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An H1 receptor antihistamine that competes with histamine for receptor sites on the target cells in the respiratory tract, intestines, blood vessels and skin | |
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[Histamine H1 receptor, Antagonist] | |
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68-88-2 | |
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200-693-1 | |
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Psycholeptics: Anxiolytics | |
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QN05BB01 | |
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No | |
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374.90 | |
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(±)-2-(2-(4-((4-chlorophenyl)-phenylmethyl)piperazin-1-yl)ethoxy)ethanol | |
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(±)-2-(2-(4-((4-chlorophenyl)-phenylmethyl)piperazin-1-yl)ethoxy)ethanol | |
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2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol | |
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Oily liquid |
Formulations |
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Vistaril | Pfizer | Not licensed | Not licensed | ||||||
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428 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
Moderate | ||||||||
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193 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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220 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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2.29 X 1002 | Calculated | - | |||||||
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2.36 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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2.47 (amine) | V2 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) estimated2 = Unverified data of unknown source |
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pKa2 = 6.95 (amine) estimated | |||||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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950 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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950 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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Intraveous LD₅₀ = 45 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 45 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Hepatic metabolisim with excretion via urine and faceces | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause increased sedation and possible hypotension May cause drowsiness, somnolence, headache, weakness, depression, and irritability May be teratogenic |
Handling issues |
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May emit toxic fumes when heated to decomposition Not compatible with strong oxidising agents |
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Not listed (Not listed) | |||
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hydroxyzine | ||
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hidroxizina | ||
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Record last updated: | 09/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |