Mirtazapine |
Last updated: 09/02/2024 |
(Not known by any other names) |
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A veterinary substance which is a noradrenergic and specific serotonergic antidepressant (NaSSA) | |
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Current | |
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1966, introduced USA | |
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Mainly used to manage anorexia and behavioral disorders in domestic pets | |
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Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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isomeric mixture | |
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C₁₇H₁₉N₃ | |
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CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4 | |
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No data | |
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RONZAEMNMFQXRA-UHFFFAOYSA-N | |
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InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3 | |
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Yes |
General status |
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Medicinal drug: antidepressant | |
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Piperazino-azepine | |
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Acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative feedback to the presynaptic nerve and causing an increase in NE release. | |
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[5-hydroxytryptamine receptor 2A, Antagonist], [5-hydroxytryptamine receptor 3A, Antagonist], [Alpha-2A adrenergic receptor, Antagonist], [5-hydroxytryptamine receptor 2C, Antagonist], [Kappa-type opioid receptor, Agonist], [Histamine H1 receptor, Antagonist], [Histamine H1 receptor, Unknown action] | |
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61337-67-5 | |
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288-060-6 | |
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Antidepressant: Psychoanaleptics | |
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QN06AX11 | |
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No | |
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265.35 | |
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(±)-2-methyl-1,2,3,4,10,14b-hexahydropyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine | |
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(±)-2-methyl-1,2,3,4,10,14b-hexahydropyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine | |
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Cream to white coloured powder |
Formulations |
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Mirataz Transdermal Ointment | Dechra Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Often formulated as transdermal ointments |
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1.1 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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114 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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7.94 X 1002 | Calculated | - | |||||||
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2.9 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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320 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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6.92 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Pimephales promelas3 = Unverified data of known source |
Moderate | ||||||||
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19.9 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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0.24 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
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General |
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320 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat3 = Unverified data of known source |
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Mirtazapine is extensively metabolized and eliminated via the urine | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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Possible CNS toxicant May cause drowsiness, dry mouth, nausea, diarrhoea and insomnia Bone marrow depression has been reported |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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mirtazapine | ||
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mirtazapina | ||
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Record last updated: | 09/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |