Moxifloxacin (Ref: BAY 12-8039) |
Last updated: 21/05/2024 |
(Not known by any other names) |
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A human and veterinary antimicrobial drug, usually used as the hydrochloride salt, active against both gram-positive and gram-negative bacteria. | |
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Mainly used for pneumonia as well as skin and soft tissue infections, particularly those caused by resistant strains of mycobacterium. Effective against infections caused by Escherichia coli, Bacteroides fragilis, Streptococcus anginosus, Streptococcus constellatus | |
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Dogs; Cats; Rodents; Monkeys |
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Not approved | |
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Not approved |
Chemical structure |
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C₂₁H₂₄FN₃O₄ | |
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COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O | |
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COC1=C2C(=CC(=C1N3C[C@@H]4CCCN[C@@H]4C3)F)C(=O)C(=CN2C5CC5)C(=O)O | |
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FABPRXSRWADJSP-MEDUHNTESA-N | |
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InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1 | |
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Common Name | Relationship | Link |
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Moxifloxacinium chloride monohydrate | Variant |
General status |
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Medicinal drug: antibacterial; antimicrobial | |
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Fluoroquinolone | |
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Synthetic | |
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Binds to and inhibits the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, resulting in inhibition of DNA replication and repair and cell death in sensitive bacterial species | |
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[DNA gyrase subunit A, Inhibitor], [DNA topoisomerase 4 subunit A, Inhibitor], [DNA topoisomerase 2-alpha, Inhibitor] | |
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354812-41-2 | |
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604-773-0 | |
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Antibacterials for systemic use - Quinolone antibacterials; Ophthalmologicals - Antiinfectives | |
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QJ01MA14; QS01AE07 | |
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No | |
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401.43 | |
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1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo(4.3.0)nonan-8-yl)-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid | |
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1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo(4.3.0)nonan-8-yl)-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid | |
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White solid |
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Avelox | Bayer Healthcare | Not licensed | Not licensed | ||||||
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1146 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
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209 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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7.94 X 1002 | Calculated | - | |||||||
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2.9 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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Excretion is mainly faecal with urinary excretion of the unchanged drug accounting for 19-22% | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May weaken & cause pain to tendons May cause dizziness, drowsiness, light-headedness, or blurred vision |
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Will emit toxic fumes when heated to decompostion | |||
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Health: H302, H319 Environment: H412 |
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Not listed (Not listed) | |||
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Not regulated | |||
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moxifloxacin | ||
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Record last updated: | 21/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |