Nitarsone |
Last updated: 24/07/2024 |
(Also known as: 4-nitrobenzenearsonic acid; 4-NPA; 4-nitarsone) |
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An organoarsenic compound once used in poultry production as a feed additive | |
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Current but withdrawn from sale in many countries | |
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Used to increase weight gain, improve feed efficiency and prevent disease | |
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Poultry - chickens, turkeys |
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Not approved | |
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Not approved |
Chemical structure |
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C₆H₆AsNO₅ | |
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C1=CC(=CC=C1[N+](=O)[O-])[As](=O)(O)O | |
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No data | |
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FUUFQLXAIUOWML-UHFFFAOYSA-N | |
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InChI=1S/C6H6AsNO5/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4H,(H2,9,10,11) | |
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Yes |
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Common Name | Relationship | Link |
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nitarsone | - |
General status |
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Antiprotozoal, Antihistomonad | |
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Organometal; Nitrobenzene | |
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>95% | |
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EFSA: inorganic arsenic <1% | |
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Synthetic | |
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Inhibitor of mitochondrial ATP synthase. | |
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Multiple targets including:[Actin, alpha cardiac muscle 1, Binding], [Actin, alpha skeletal muscle, Binding], [Actin, aortic smooth muscle, Binding], [Actin, cytoplasmic 1, unknown action] | |
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98-72-6 | |
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202-695-8 | |
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None allocated | |
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No | |
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247.04 | |
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(4-Nitrophenyl)arsonic acid | |
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(4-Nitrophenyl)arsonic acid | |
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p-Nitrophenyl)arsonic acid | |
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Formulations |
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Histostat | Alphama Inc | Not licensed | Not licensed | ||||||
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3.8 | V2 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 2 = Unverified data of unknown source |
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298 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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298 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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3.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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arsanilic acid | - | Turkeys | - |
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Terrestrial ecotoxicology |
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130 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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130 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Intraperitoneal LD₅₀ = 46.5 mg kg⁻¹ | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Intravenous LD₅₀ = 18.0 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Eliminated in excreta | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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nitarsone | ||
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nitarson | ||
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Record last updated: | 24/07/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |