Nystatin |
Last updated: 23/02/2024 |
(Not known by any other names) |
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A human and veterinary medicine used to treat fungal infections such as yeasts and moulds. | |
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Current | |
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1950, first isolated from bacteria | |
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Mainly used to treat oral (such as Candidiasis) or gastrointestinal tract infections | |
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Cats; Dogs; Pet birds (budgerigars, lovebirds, finches, parrotlets, and cockatiels); Reptiles |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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No data | |
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C₄₇H₇₅NO₁₇ | |
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CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O | |
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C[C@H]1/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(CC2C(C(C[C@](O2)(CC(C(CCC(CC(CC(CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O | |
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VQOXZBDYSJBXMA-RKEBNKJGSA-N | |
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InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1 | |
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Yes |
General status |
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Medicinal drug: Antifungal | |
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Bacterial origin | |
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Natural | |
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Binds to ergosterol, a major component of the fungal cell membrane. As concentrations build pores in the membrane develop leading to K+ leakage, acidification and fungal cell death | |
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[Ergosterol, Binder] | |
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1400-61-9 | |
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215-749-0 | |
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202800 | |
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6433272 | |
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Intestinal Antiinfectives - Antidiarrheals, intestinal antiinflammatory/antiinfective agents; Antifungals for topical use - Antifungals for dermatological use | |
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QA07AA02; QD01AA01 | |
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No | |
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926.09 | |
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(1S,3R,4R,7R,9R,11R,15S,16R,17R,18S,19E,21E, 25E,27E,29E,31E,33R,35S,36R,37S)-33-((3-amino-3,6-dideoxy-β-L-mannopyranosyl)oxy)-1, 3,4,7,9,11,17,37-octahydroxy-15, 16,18-trimethyl-13-oxo-14, 39-dioxabicyclo(33.3.1)nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid | |
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(1S,3R,4R,7R,9R,11R,15S,16R,17R,18S,19E,21E, 25E,27E,29E,31E,33R,35S,36R,37S)-33-((3-amino-3,6-dideoxy-β-L-mannopyranosyl)oxy)-1, 3,4,7,9,11,17,37-octahydroxy-15, 16,18-trimethyl-13-oxo-14, 39-dioxabicyclo(33.3.1)nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid | |
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Formulations |
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Canaural Ear Drops Suspension | Dechra Veterinary Products A/S | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Current products are mainly formulated as ear drops |
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360 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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160 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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250 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.58 X 10-03 | Calculated | - | |||||||
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-2.8 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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10000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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55.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Meleagris gallopavo NOEL3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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10000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LD₅₀ = 4.4 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ = 3.0 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Mainly fecal elimination | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause diarrhoea & abdominal pain Harmful if swallowed in high doses |
Handling issues |
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May be combustible in some formulations Not compatible with strong oxidising agents Will emit toxic fumes if heated to decomposition |
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Not listed (Not listed) | |||
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Not regulated | |||
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nystatin | ||
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nystatine | ||
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Nistatina | ||
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Record last updated: | 23/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |