Oxymorphone (Ref: EN3202) |
Last updated: 09/02/2024 |
(Also known as: dihydroxymorphinone) |
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A human and veterinary morphine derivative, opioid pain medication usually used as the hydrochloride salt | |
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Current | |
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1914, first developed Germany | |
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Used for severe pain management and as an induction agent for sedation | |
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Dogs; Cats; Elephants |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₇H₁₉NO₄ | |
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CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O | |
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CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O | |
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UQCNKQCJZOAFTQ-ISWURRPUSA-N | |
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InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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oxymorphone | Hydrate |
General status |
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Medicinal drug: analgesic | |
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Opioid | |
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Synthetic | |
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Acts by binding to and activating the mu opioid receptor (MOR) | |
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[Mu-type opioid receptor, Agonist], [Delta-type opioid receptor, Antagonist] | |
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76-41-5 | |
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200-959-7 | |
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Nervous system: Natural opium alkaloids | |
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QN02AA11 | |
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UK: Class A, Schedule 2; EU UN61/72, Class I | |
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301.34 | |
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4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one | |
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4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one | |
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7,8-dihydro-14-hydroxymorphinone | |
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Crystalline solid |
Formulations |
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Opana | Endo Pharmaceuticals Inc., USA | Not licensed | Not licensed | ||||||
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24000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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248 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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248 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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6.76 X 1000 | Calculated | - | |||||||
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0.83 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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8.17 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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140 | R3 R = Peer reviewed scientific publications Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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140 | R3 R = Peer reviewed scientific publications Rat3 = Unverified data of known source |
Moderate | ||||||||
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Intravenous LD₅₀ = 172 mg kg⁻¹ | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 200 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Highly metabolised in the liver | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Health issues |
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CNS toxicant May cause constipation, nausea, vomiting, dizziness May cause severe allergic reactions - rash, hives, itching, difficulty breathing, chest tightness, swelling of the mouth, face, lips, tongue |
Handling issues |
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Not compatible with alkalies or strong oxidising materials Ignited dusts may cause an explosion Will emit toxic gases when heated to decomposition |
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Not listed (Not listed) | |||
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Not regulated | |||
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oxymorphone | ||
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oximorfona | ||
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Record last updated: | 09/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |