Robenacoxib |
Last updated: 18/01/2024 |
(Not known by any other names) |
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A nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine | |
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Current | |
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Used for pain, fever and inflamation relief especially that associated with musculoskeletal disorders | |
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Cats; Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₁₆H₁₃F₄NO₂ | |
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CCC1=CC(=C(C=C1)NC2=C(C(=CC(=C2F)F)F)F)CC(=O)O | |
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No data | |
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ZEXGDYFACFXQPF-UHFFFAOYSA-N | |
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InChI=1S/C16H13F4NO2/c1-2-8-3-4-12(9(5-8)6-13(22)23)21-16-14(19)10(17)7-11(18)15(16)20/h3-5,7,21H,2,6H2,1H3,(H,22,23) | |
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Yes |
General status |
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Medicinal drug: NSAID | |
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Coxib | |
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Synthetic | |
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Selectively inhibits the cyclooxygenase 2 enzyme (COX-2). | |
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[Cyclo-oxygenase 2 (COX-2), Inhibitor] | |
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220991-32-2 | |
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Anti-inflammatory and antirheumatic products: Coxibs | |
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QM01AH91 | |
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No | |
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327.28 | |
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2-(5-ethyl-2-(2,3,5,6-tetrafluoroanilino)phenyl)acetic acid | |
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(5-ethyl-2-((2,3,5,6-tetrafluorophenyl)amino)phenyl)acetic acid | |
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Soild |
Formulations |
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Onsior 10 mg Tablets for Dogs | Elanco Europe Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Onsior 20 mg/ml Solution for Injection for Cats and Dogs | Elanco Europe Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Robexera Chewable Tablets | Krka, d.d. Novo mesto | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available in a range of formulations including solutions for injection and tablets for oral administration |
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1.06 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 500 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat4 = Verified data |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 100 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
Low | ||||||||
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> 100 | E4 E = Manufacturers safety data sheets Selenastrum capricornutum4 = Verified data |
Low | ||||||||
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General |
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> 500 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat4 = Verified data |
Moderate | ||||||||
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Intraperitoneal LD₅₀ > 200 mg kg⁻¹ | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat4 = Verified data |
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Excreted predominately via the biliary route in dogs & cats | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
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Health issues |
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May induce gastrointestinal problems including vomiting and diarrhoea |
Handling issues |
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May produce harmful or irritant substances when heated to decomposition | |||
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Not listed (Not listed) | |||
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None allocated | |||
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robenacoxib | ||
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robénacoxib | ||
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Robénacoxib | ||
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robénacoxib | ||
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Record last updated: | 18/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |