Sucralfate |
Last updated: 12/01/2024 |
(Also known as: sulfated disaccharide, aluminium salt) |
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A sucrose aluminum hydroxide compound used to treat various gastrointestinal and oral issues | |
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Current | |
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1932, first developed as an antipeptic agent | |
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Used for the prevention and treatment of ulcers in the mouth, esophagous, stomach, and intestines | |
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Cats; Dogs; Ferrets; Chinchillas; Reptiles; Birds |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₁₂H₅₄Al₁₆O₇₅S₈ | |
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C(C1C(C(C(C(O1)OC2(C(C(C(O2)OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al].O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O | |
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C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al].O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O | |
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MNQYNQBOVCBZIQ-JQOFMKNESA-A | |
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Yes |
General status |
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Medicinal drug: anti-ulcer | |
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Disaccharides | |
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Synthetic | |
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Acts as a stomach acid buffer | |
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[Pepsin, Inhibitor], [Fibroblast growth factor 2, Agonist], [Pro-epidermal growth factor, Inducer], [Fibrinogen alpha chain, Antagonist], [Fibrinogen beta chain, Antagonist], [Fibrinogen gamma chain, Antagonist] | |
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54182-58-0 | |
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259-018-4 | |
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Drugs for peptic ulcers and gastro-oesophageal reflux disease | |
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QA02BX02 | |
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No | |
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974.74 | |
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hexadeca-µ-hydroxytetracosahydroxy(µ8-91,3,4,6-tetra-O-sulfo-β-Dfructofuranosyl-a-D-glucopyranoside tetrakis(hydrogen sulfato)8-)))hexadecaaluminum | |
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hexadeca-µ-hydroxytetracosahydroxy(µ8-91,3,4,6-tetra-O-sulfo-β-Dfructofuranosyl-a-D-glucopyranoside tetrakis(hydrogen sulfato)8-)))hexadecaaluminum | |
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aluminium sucrose octasulphate | |
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White to yellow coloured amorphous powder |
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Antepsin | Idis pharma | Not licensed | Not licensed | ||||||
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Usually formulated as tablets or solution for oral administration for gastrointestinal issues. For those of the mouth products may be formulated as gels to set into a covering over ulcerated or eroded tissues acting as a protectant bandage. |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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V3 Rat 12000 | - | Low | ||||||||
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Intraperitoneal LD₅₀ > 4000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Subcutaneous LD₅₀ > 12000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Excreted mainly unchanged in the faeces in 24 hours | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Health issues |
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May cause consipation Possible kidney toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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sucralfate | ||
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sucralfato | ||
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sucralfato | ||
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Record last updated: | 12/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |