Triamcinolone acetonide |
Last updated: 21/05/2024 |
(Also known as: AL-938; Alcon) |
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A synthetic glucocorticoid used topically in veterinary medicine | |
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Current | |
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circa late-1950s, introduced | |
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Used for the control of pruritus, allergies and as a preinductor and/or inductor of birth in cows | |
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Dogs; Cats; Cattle; Horses |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₄H₃₁FO₆ | |
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CC1(OC2CC3C4CCC5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)C | |
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C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@@]53C)F)O | |
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YNDXUCZADRHECN-JNQJZLCISA-N | |
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InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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triamcinolone acetonide | - |
General status |
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Medicinal drug: Anti-irritant; Anti-inflammatory agent | |
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Corticosteroid | |
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Synthetic | |
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Corticosteroids have been shown to have a wide range of actions on multiple cell types and mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. | |
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[Glucocorticoid receptor, Agonist] | |
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76-25-5 | |
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200-948-7 | |
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Corticosteroids and antiinfectives in combination | |
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QS02CA04 | |
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No | |
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434.50 | |
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(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho(2',1':4,5)indeno(1,2-d)(1,3)dioxol-2-one | |
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(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho(2',1':4,5)indeno(1,2-d)(1,3)dioxol-2-one | |
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9-α-fluoro-16-hydroxyprednisolone acetonide | |
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White powdery solid |
Formulations |
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Dermanolon Cutaneous sprat | Le Vet Beheer B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Recicort Ear Drops | Le Vet Beheer Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available as ready to use sprays and eardrops |
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21.0 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 28 °C3 = Unverified data of known source |
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187 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.45 X 1001 | Calculated | - | |||||||
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1.16 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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> 5000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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> 5000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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402 | E3 E = Manufacturers safety data sheets Rabbit3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 105 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 13.1 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Metabolised in the liver and excreted by the kidneys | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May have immunosuppressive effects Will be absorbed through the skin May cause Cushing's syndrome May cross the placenta |
Handling issues |
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Will emit toxic and irritating fumes if heated to decomposition | |||
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Health: H334, H317, H360 | |||
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Not listed (Not listed) | |||
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triamcinolone acetonide | ||
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Record last updated: | 21/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |