Fenthion (Ref: OMS 2) |
Last updated: 23/08/2024 |
(Also known as: MPP; ENT 25540; Bayer 29493; S-1752; BAY 29493; DMTP) |
SUMMARY |
Fenthion is an insecticide for sucking and chewing pests. It has a low water solubility but is generally highly soluble in organic solvents. It is volatile and is not expected to leach to groundwater. Its persistence in soil and water systems depends on local conditions. It is moderately toxic to mammals and a cholinesterase inhibitor. Fenthion is highly toxic to birds and honeybees and has a high to moderate toxicity to most aquatic species and earthworms. |
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A organophosphate insecticide used in veterinary medicine for external parasite control | |
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Current | |
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1960, first reported & introduced | |
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Used to to control lice, fleas, ticks, flies and other external parasites | |
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Cattle; Pigs; Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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None | |
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C₁₀H₁₅O₃PS₂ | |
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CC1=C(C=CC(=C1)OP(=S)(OC)OC)SC | |
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- | |
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PNVJTZOFSHSLTO-UHFFFAOYSA-N | |
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InChI=1S/C10H15O3PS2/c1-8-7-9(5-6-10(8)16-4)13-14(15,11-2)12-3/h5-7H,1-4H3 | |
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Yes |
General status |
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Insecticide, Antiparasitic | |
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Organophosphate insecticide | |
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- | |
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- | |
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Synthetic | |
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Contact, stomach and respiratory action. Acetylcholinesterase (AchE) inhibitor. | |
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[Cholinesterase, Inhibitor] | |
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55-38-9 | |
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200-231-9 | |
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79 | |
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053301 | |
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3346 | |
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015-048-00-8 | |
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Antiparasitic products, insecticides & repellents: Ectoparasiticides | |
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QP53BB02 | |
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No | |
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- | |
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278.33 | |
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O,O-dimethyl O-[3-methyl-4-(methylsulfanyl)phenyl] phosphorothioate | |
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O,O-dimethyl O-4-methylthio-m-tolyl phosphorothioate | |
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O,O-dimethyl O-(3-methyl-4-(methylthio)phenyl) phosphorothioate | |
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Severe Marine Pollutant; Evidence of use in third world countries; Chemical subject to PIC regulations; Highly toxic to birds | |
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- | |
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Colourless oily liquid | |
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Formulations |
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- | - | - | - | ||||||
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- |
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4.2 | H4 H = The US ARS pesticide properties database. Dataset is no longer available. 4 = Verified data |
Low | ||||||||
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100000 | L3 L = Pesticide manuals and hard copy reference books / other sources Hexane3 = Unverified data of known source |
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250000 | L3 L = Pesticide manuals and hard copy reference books / other sources Toluene3 = Unverified data of known source |
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250000 | L3 L = Pesticide manuals and hard copy reference books / other sources Dichloromethane3 = Unverified data of known source |
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250000 | L3 L = Pesticide manuals and hard copy reference books / other sources Isopropanol3 = Unverified data of known source |
- | |||||||||
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7.5 | AC4 AC = EC Joint Research Centre ESIS European Chemical Substance Information Systems including EINECS, now integrated with the database provided by the European Chemicals Agency (ECHA) (click here ) 4 = Verified data |
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90 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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- | - | - | ||||||||
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170 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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6.92 X 1004 | Calculated | - | |||||||
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4.84 | H4 H = The US ARS pesticide properties database. Dataset is no longer available. 4 = Verified data |
High | ||||||||
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Soluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Regulatory data - observed in metabolism and farm animal feeding studies | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.25 | AC4 AC = EC Joint Research Centre ESIS European Chemical Substance Information Systems including EINECS, now integrated with the database provided by the European Chemicals Agency (ECHA) (click here ) 4 = Verified data |
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- | - | - | ||||||||
- | |||||||||||
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0.37 | H4 H = The US ARS pesticide properties database. Dataset is no longer available. 4 = Verified data |
Low volatility. If applied directly to plants, drift is a concern & mitigation is advisable | ||||||||
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2.40 X 10-02 | H4 H = The US ARS pesticide properties database. Dataset is no longer available. 4 = Verified data |
Non-volatile | ||||||||
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- |
Degradation |
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22 | W4 W = French database provided by ARVALIS-Institut du Végétal. Dataset no longer available. 4 = Verified data |
Non-persistent | |||||||
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34 | DW4 DW = Don Wauchope personal database for Pka data: Wauchope, R. D. and Edwards, J. Dissociation constants for pesticide active ingredients: a database and comparison with predicted values. Dataset is no longer available. 4 = Verified data |
Moderately persistent | ||||||||
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Data variable DT₅₀ ranges 1(aerobic) - 34 days | ||||||||||
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0.4 | AC4 AC = EC Joint Research Centre ESIS European Chemical Substance Information Systems including EINECS, now integrated with the database provided by the European Chemicals Agency (ECHA) (click here ) 4 = Verified data |
Fast | |||||||
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- | ||||||||||
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Stable | W4 W = French database provided by ARVALIS-Institut du Végétal. Dataset no longer available. 4 = Verified data |
Stable | |||||||
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- | ||||||||||
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92 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderately fast | ||||||||
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- | - | - | ||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | G3 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 3 = Unverified data of known source |
Slightly mobile | |||||||
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1500 | ||||||||||
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- | ||||||||||
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Fate indices |
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1.26 | Calculated | Low leachability | ||||||||||||||||||||||||||
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154 | R3 R = Peer reviewed scientific publications Whole body (Other literature Log BCF range 1.0-2.3 (3 = Unverified data of known source R3 R = Peer reviewed scientific publications ))3 = Unverified data of known source |
Threshold for concern | |||||||||||||||||||||||||
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5 | - |
Known soil metabolites |
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Known groundwater metabolites |
None
Other known metabolites |
None
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Terrestrial ecotoxicology |
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586 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Moderate | ||||||||
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- | L2 L = Pesticide manuals and hard copy reference books / other sources Rat 2 yr2 = Unverified data of unknown source |
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5 | - | |||||||||
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7.2 | E3 E = Manufacturers safety data sheets Colinus virginianus3 = Unverified data of known source |
High | ||||||||
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- | - | - | ||||||||
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375 | E3 E = Manufacturers safety data sheets Eisenia foetida3 = Unverified data of known source |
Moderate | ||||||||
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Nitrogen mineralisation: >25% effect Carbon mineralisation: No significant adverse effect |
AC4 AC = EC Joint Research Centre ESIS European Chemical Substance Information Systems including EINECS, now integrated with the database provided by the European Chemicals Agency (ECHA) (click here ) 4 = Verified data Dose: 10 uL/kg soil 20 °C |
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> 0.308 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Apis mellifera3 = Unverified data of known source |
High | |||||||
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Aquatic ecotoxicology |
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0.8 | E3 E = Manufacturers safety data sheets Oncorhynchus mykiss3 = Unverified data of known source |
Moderate | ||||||||
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0.12 | P3 P = Other non-EU, UK or US Governments and Regulators Pimephales promelas 30 day3 = Unverified data of known source |
Moderate | ||||||||
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4.25 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio EC₅₀ Embryo3 = Unverified data of known source |
Moderate | ||||||||
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0.0057 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
High | ||||||||
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0.000013 | P4 P = Other non-EU, UK or US Governments and Regulators Daphnia magna4 = Verified data |
High | ||||||||
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0.0015 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ceriodaphnia dubia4 = Verified data |
High | ||||||||
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0.00018 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Americamysis bahia4 = Verified data |
High | ||||||||
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0.0078 | R4 R = Peer reviewed scientific publications Chironomus salinarius 24 hr4 = Verified data |
High | ||||||||
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1.79 | L3 L = Pesticide manuals and hard copy reference books / other sources Scenedesmus subspicatus3 = Unverified data of known source |
Moderate | ||||||||
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> 0.3 | P3 P = Other non-EU, UK or US Governments and Regulators Pseudokirchneriella subcapitata 48 hr3 = Unverified data of known source |
Moderate | ||||||||
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- | - | - |
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General |
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High (class III) | - | - | ||||||||
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586 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Moderate | ||||||||
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1680 | AC4 AC = EC Joint Research Centre ESIS European Chemical Substance Information Systems including EINECS, now integrated with the database provided by the European Chemicals Agency (ECHA) (click here ) Rat4 = Verified data |
- | ||||||||
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1.2 | AC4 AC = EC Joint Research Centre ESIS European Chemical Substance Information Systems including EINECS, now integrated with the database provided by the European Chemicals Agency (ECHA) (click here ) Rat 4 = Verified data |
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Intraperitoneal LD₅₀ = 260 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 320 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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0.01 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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List I; List II | - | - | ||||||||
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Ingestion main poisoning route | ||||||||||
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Excreted in the faeces and urine almost completely after 3days | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Harmful in contact with skin or if inhaled or swallowed May harm central nervous, cardiovascular, and respiratory systems Suspected of causing genetic defects |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Health: H302, H312, H331, H341 Environment: H400, H410 |
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II (Moderately hazardous) | |||
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UN3018 | |||
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fenthion | ||
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fenthion | ||
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Fenthion | ||
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fenthion | ||
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fention | ||
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fention | ||
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fenthion | ||
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fention | ||
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fention | ||
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fenthion | ||
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Record last updated: | 23/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |