Fenvalerate (Ref: OMS 2000) |
Last updated: 23/08/2024 |
(Not known by any other names) |
SUMMARY |
Fenvalerate is a pyrethroid, non-systemic acaricide. It has a low aqueous solubility and has a low volatility. Evidence suggests it is moderately persistent in both soil and water systems. Based on its physico-chemical properties it is not expected to leach to groundwater. It is highly toxic to most aquatic organisms and to bees. It has a moderate mammalian oral toxicity and is a recognised irritant. |
|
|
A pyrethroid insecticideonce used in veterinary medicine for parasite management | |
---|---|---|
|
Current | |
|
1976, introduced | |
|
Used to control external parasites such as flies and ticks on livestock and in stables | |
|
Cattle; Horses; Pigs; Dogs |
Approval status |
|
Not approved | |
---|---|---|
|
Not approved |
Chemical structure |
|
A molecule with 2 chiral centres, fenvalerate is a mixture of four optical isomers which have different insecticidal activities. The 2-S alpha (or SS) configuration is the most insecticidally active isomer. | |
---|---|---|
|
C₂₅H₂₂ClNO₃ | |
|
CC(C)C(C1=CC=C(C=C1)Cl)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3 | |
|
- | |
|
NYPJDWWKZLNGGM-UHFFFAOYSA-N | |
|
InChI=1S/C25H22ClNO3/c1-17(2)24(18-11-13-20(26)14-12-18)25(28)30-23(16-27)19-7-6-10-22(15-19)29-21-8-4-3-5-9-21/h3-15,17,23-24H,1-2H3 | |
|
Yes |
General status |
|
Insecticide | |
---|---|---|
|
Pyrethroid insecticide; Pyrthroid acaricide; Pyrethroid ester insecticide; Pyrethroid ester acaricide | |
|
92% | |
|
- | |
|
Synthetic | |
|
Non-systemic with contact and stomach action. Sodium channel modulator. | |
|
[Sodium channel, Modulator] | |
|
51630-58-1 | |
|
257-326-3 | |
|
334 | |
|
109301 | |
|
3347 | |
|
No data found | |
|
Antiparasitic products, insecticides & repellents: Pyrethrins & pyrethroids / Other ectoparasiticides for topical use | |
|
QP53AC14 / QP53AX02 | |
|
No | |
|
- | |
|
419.90 | |
|
(E)-cyano(3-phenoxyphenyl)methyl (2E)-2-(4-chlorophenyl)-3-methylbutanoate | |
|
(RS)-α-cyano-3-phenoxybenzyl (RS)-2-(4-chlorophenyl)-3-methylbutyrate | |
|
cyano(3-phenoxyphenyl)methyl 4-chloro-α-(1-methylethyl)benzeneacetate | |
|
Chemical subject to PIC regulations | |
|
- | |
|
Viscous yellow-brown liquid |
Formulations |
|
|
|
|
|
||||||
---|---|---|---|---|---|---|---|---|---|---|
|
Tirade | Sumitomo | Not licensed | Not licensed | ||||||
Sumifly | Sumitomo | Not licensed | Not licensed | |||||||
|
- |
|
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.001 | K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data |
Low | ||||||||
|
53000 | L3 L = Pesticide manuals and hard copy reference books / other sources n-Hexane3 = Unverified data of known source |
- | ||||||||
200000 | L3 L = Pesticide manuals and hard copy reference books / other sources Xylene3 = Unverified data of known source |
- | |||||||||
84000 | L3 L = Pesticide manuals and hard copy reference books / other sources Methanol3 = Unverified data of known source |
- | |||||||||
|
39.5 | E4 E = Manufacturers safety data sheets 4 = Verified data |
- | ||||||||
|
Decomposes on distillation | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
|
230 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
- | ||||||||
|
|
1.02 X 1005 | Calculated | - | |||||||
|
5.01 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
High | ||||||||
|
|
Soluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | |||||||
|
Regulatory data - observed in metabolism and farm animal feeding studies | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
|
1.175 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
0.0192 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Low volatility | ||||||||
|
4.20 X 10-02 | H4 H = The US ARS pesticide properties database. Dataset is no longer available. 4 = Verified data |
Non-volatile | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- |
Degradation |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
40 | M4 M = GLEAMS Model database (Groundwater Loading Effects of Agricultural Management Systems). Dataset no longer available. 4 = Verified data |
Moderately persistent | |||||||
|
77 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Moderately persistent | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
Other sources: DT₅₀ 35 days (DW4) | ||||||||||
|
- | - | - | ||||||||
|
|
9.2 | K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data |
Moderately fast | |||||||
|
- | ||||||||||
|
|
115 | K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data |
Persistent | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
|
[Wheat grain: >50 wks @ 30 DegC, 50% RH; Modelled data] |
Soil adsorption and mobility |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | H3 H = The US ARS pesticide properties database. Dataset is no longer available. 3 = Unverified data of known source |
Non-mobile | |||||||
|
5273 | ||||||||||
|
- | ||||||||||
|
|
13.11 | R4 R = Peer reviewed scientific publications 4 = Verified data |
- | |||||||
|
- | ||||||||||
|
0.96 | ||||||||||
|
Soil with 68% loam, 24% silt, 8% clay, pH 6.5, OC=2.1% | ||||||||||
|
- |
Fate indices |
|
|
|
|
||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.52 | Calculated | Low leachability | ||||||||||||||||||||||||||
|
|
1664 | P4 P = Other non-EU, UK or US Governments and Regulators (Other literature log BCF range 2.6-3.6 (R3))4 = Verified data |
Threshold for concern | |||||||||||||||||||||||||
|
Not available | - |
Known metabolites |
None
|
Terrestrial ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
451 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Moderate | ||||||||
|
|
- | L2 L = Pesticide manuals and hard copy reference books / other sources Rat 2 yr2 = Unverified data of unknown source |
- | |||||||
|
250 | - | |||||||||
|
- | - | - | ||||||||
|
9932 | L3 L = Pesticide manuals and hard copy reference books / other sources Anas platyrhynchos3 = Unverified data of known source |
Low | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
40 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | - | - | |||||||||
|
|
0.23 | E3 E = Manufacturers safety data sheets Apis mellifera3 = Unverified data of known source |
High | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
- | |||||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
|
1.09 | R4 R = Peer reviewed scientific publications Trigona spinipes4 = Verified data |
Moderate | |||||||
|
Contact | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
> 5.84 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Coccinella septempunctata Adult4 = Verified data |
- | ||||||||
|
> 30.2 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Chrysoperla carnea Larva4 = Verified data |
- | ||||||||
|
- | - | - | ||||||||
|
Harmful | AA2 AA = IOBC Database on classification of side effects to beneficial organisms, 2005 Typhlodromus pyri2 = Unverified data of unknown source |
- | ||||||||
|
- | - | - |
Aquatic ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.0036 | L3 L = Pesticide manuals and hard copy reference books / other sources Oncorhynchus mykiss3 = Unverified data of known source |
High | ||||||||
|
0.002 | P3 P = Other non-EU, UK or US Governments and Regulators Clarias batrachus 14 day3 = Unverified data of known source |
High | ||||||||
|
> 0.005 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio Larva3 = Unverified data of known source |
High | ||||||||
|
0.001 | P3 P = Other non-EU, UK or US Governments and Regulators Daphnia magna3 = Unverified data of known source |
High | ||||||||
|
> 0.00003 | P3 P = Other non-EU, UK or US Governments and Regulators Daphnia magna3 = Unverified data of known source |
High | ||||||||
|
- | - | - | ||||||||
|
0.000005 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Americamysis bahia3 = Unverified data of known source |
High | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
50 | W2 W = French database provided by ARVALIS-Institut du Végétal. Dataset no longer available. Unknown species2 = Unverified data of unknown source |
Low | ||||||||
|
5.0 | P3 P = Other non-EU, UK or US Governments and Regulators Synechococcus elongatus 14 day3 = Unverified data of known source |
Low | ||||||||
|
|
- | - | - |
|
- | - | - |
|
General |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
High (class III) | - | - | ||||||||
|
451 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Moderate | ||||||||
|
1000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rabbit3 = Unverified data of known source |
- | ||||||||
|
> 0.101 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
|
0.0125 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | |||||||||
|
- | ||||||||||
|
Slow elimination (6-8 days). Partial elimination in feces with minimal excretion in urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
- |
Health issues |
|
|
||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
May cause abdominal pain, convulsions and vomiting if ingested Cardiovascular and blood toxicant IARC Group 3 carcinogen - not classifiable Endocrine issues - Inhibition of estrogen-sensitive cells proliferation |
Handling issues |
|
|
|||
---|---|---|---|---|
|
IMDG Transport Hazard Class 6.1 | |||
|
Health: H301, H315, H319, H332, H335 Environment: H400, H410 |
|||
|
II (Moderately hazardous) | |||
|
UN2811 | |||
|
- | |||
|
Limited shelf-life |
|
|
|
||
---|---|---|---|
|
fenvalerate | ||
|
fenvalérate | ||
|
Fenvalerat | ||
|
fenvalerat | ||
|
fenvalerate | ||
|
fenvalerato | ||
|
- | ||
|
fenwalerat | ||
|
- | ||
|
- | ||
|
fenvaleraat | ||
|
- |
Record last updated: | 23/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |