Sarolaner |
Last updated: 23/02/2024 |
(Not known by any other names) |
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An orally administered isoxazoline systemic insecticide and acacide | |
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Current | |
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circa 2014, introduced | |
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Used for the treatment of fleas, ticks and other parasites. It is also used as part of a treatment strategy for the control of Flea Allergy Dermatitis | |
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Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric - the product Sarolaner is the chirally pure S-enantiomer | |
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C₂₃H₁₈Cl₂F₄N₂O₅S | |
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CS(=O)(=O)CC(=O)N1CC2(C1)C3=C(CO2)C=C(C=C3)C4=NOC(C4)(C5=CC(=C(C(=C5)Cl)F)Cl)C(F)(F)F | |
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CS(=O)(=O)CC(=O)N1CC2(C1)C3=C(CO2)C=C(C=C3)C4=NO[C@@](C4)(C5=CC(=C(C(=C5)Cl)F)Cl)C(F)(F)F | |
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FLEFKKUZMDEUIP-QFIPXVFZSA-N | |
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Yes |
General status |
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Insecticide, Acaracide | |
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Isoxazoline | |
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Synthetic | |
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Inhibitor of GABA-elicited currents at both susceptible (CfRDL-A285) and resistant (CfRDL-S285) flea GABACls with similar potency | |
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[GABA-gated chloride, Blocker], [Glutamate-gated chloride, blocker] | |
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1398609-39-6 | |
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Ectoparasiticide for systemic use | |
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QP53BE03 | |
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No | |
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581.36 | |
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1-(6-((5S)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl)spiro(1H-2-benzofuran-3,3'-azetidine)-1'-yl)-2-methylsulfonylethanone | |
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1-(6-((5S)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl)spiro(1H-2-benzofuran-3,3'-azetidine)-1'-yl)-2-methylsulfonylethanone | |
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Potential marine pollutant | |
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White to off-white crystals or powder |
Formulations |
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Felisecto Spot-on Solution | Zoetis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Mipet Chewable Tablets | Zoetis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Simparica Chewable Tablets | Zoetis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Formulated in a variety of ways including spot-on treatments and chewable tablets |
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1.78 X 1003 | Calculated | - | |||||||
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3.25 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 550 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 0.54 | E4 E = Manufacturers safety data sheets Oncorhynchus mykiss4 = Verified data |
Moderate | ||||||||
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> 0.27 | E4 E = Manufacturers safety data sheets Daphnis magna4 = Verified data |
Moderate | ||||||||
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0.27 | E4 E = Manufacturers safety data sheets Pseudokirchneriella subcapitata 4 = Verified data |
Moderate | ||||||||
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General |
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> 550 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Pattern of use is unlikely to result in toxicological relevant exposure | |||||||||
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Pattern of use is unlikely to result in toxicological relevant exposure | ||||||||||
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Biliary excretion with elimination via faeces | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May induce a mild neurotoxic effect |
Handling issues |
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IMDG Transport Hazard Class 9 | |||
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Health: H302 Environment: H400, H410 |
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Not listed (Not listed) | |||
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UN3077 | |||
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Packaging Group III (minor danger) | |||
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sarolaner | ||
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Record last updated: | 23/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |