Albaconazole (Ref: UR-9825) |
Last updated: 20/01/2024 |
(Not known by any other names) |
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A triazole antifungal agent that also demonstrates anti-parasitic activity. | |
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Has very potent activity against species of Candida, Cryptococcus and Aspergillus. Used with some success to treat Chagas disease and other parasitic diseases in dogs | |
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Dogs; Monkeys |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₂₀H₁₆ClF₂N₅O₂ | |
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CC(C(CN1C=NC=N1)(C2=C(C=C(C=C2)F)F)O)N3C=NC4=C(C3=O)C=CC(=C4)Cl | |
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C[C@H]([C@](CN1C=NC=N1)(C2=C(C=C(C=C2)F)F)O)N3C=NC4=C(C3=O)C=CC(=C4)Cl | |
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UHIXWHUVLCAJQL-MPBGBICISA-N | |
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InChI=1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1 | |
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Yes |
General status |
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Antifungal agent; Antiparasitic | |
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Triazole fungicide; Conazole fungicide | |
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Synthetic | |
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The drug blocks a number of CYP450 liver enzymes. | |
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[CYP4 liver enzymes, Blocker] | |
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187949-02-6 | |
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642-950-4 | |
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208952 | |
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None allocated | |
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No | |
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431.83 | |
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(1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one | |
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(1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one | |
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White to pale yellow solid |
Formulations |
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125 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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659 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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352 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.00 X 1003 | Calculated | - | |||||||
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3.0 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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149 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.667 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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Mainly eliminated in the faeces (>60%) | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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No information available |
Handling issues |
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No information available | |||
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Health: H302 | |||
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Not listed (Not listed) | |||
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albaconazole | ||
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Record last updated: | 20/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |