Pregabalin |
Last updated: 22/05/2024 |
(Not known by any other names) |
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A neuroactive veterinary drug used for dedation and as an anticonvulsant | |
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Current | |
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Used to assist with acute anxiety and fear associated with transportation and veterinary visits as well as treating epilepsy, chronic pain and seizures | |
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Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Substance is isomeric existing in the (R)- and (S)-forms. Pregabalin is the (S)-isomer and the potent of the two. | |
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C₈H₁₇NO₂ | |
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CC(C)CC(CC(=O)O)CN | |
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CC(C)C[C@@H](CC(=O)O)CN | |
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AYXYPKUFHZROOJ-ZETCQYMHSA-N | |
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InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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(R)-pregabalin | Isomer | |
pregabalin | - | |
(S)-pregabalin | Isomer |
General status |
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Sedative | |
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Alkylated analog of GABA | |
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Synthetic | |
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Binds to the auxiliary subunit (alpha2-delta protein) of voltage-gated calcium channels in the CNS thereby reducing the release of various neurotransmitters and producing its anxiolytic effect. | |
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[Alpha2-delta subunits, Binder] | |
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148553-50-8 | |
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604-639-1 | |
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5486971 | |
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Nervous system, other antiepileptics | |
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QN03AX16 | |
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UK: Class C, Schedule 3 | |
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159.23 | |
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(3S)-3-(aminomethyl)-5-methylhexanoic acid | |
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(3S)-3-(aminomethyl)-5-methylhexanoic acid | |
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Off-white coloured crystalline solid |
Formulations |
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Bonqat 50 mg/ml oral solution for cats | Orion Corp | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Usually supplied as an oral solution |
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11300 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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176 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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145 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.00 X 1001 | Calculated | - | |||||||
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1.3 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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4.2 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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pKa(2) = 10.6 | |||||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 5000 | E4 E = Manufacturers safety data sheets Rat4 = Verified data |
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Aquatic ecotoxicology |
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> 1000 | E4 E = Manufacturers safety data sheets Oncorhynchus mykiss4 = Verified data |
Low | ||||||||
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> 1000 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
Low | ||||||||
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> 300 | E4 E = Manufacturers safety data sheets Scenedesmus quadricauda4 = Verified data |
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General |
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> 5000 | E4 E = Manufacturers safety data sheets Rat4 = Verified data |
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Pattern of use is unlikely to result in toxicological relevant exposure | |||||||||
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Pattern of use is unlikely to result in toxicological relevant exposure | ||||||||||
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Elimination is primarily as an unchanged drug by renal excretion usually within 7 hrs | E4 E = Manufacturers safety data sheets 4 = Verified data |
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Health issues |
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Originally approved in US as an anti-epileptic & anticonvulsant drug May cause severe allergic reaction Possible liver toxin |
Handling issues |
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Corrosive Incompatible with strong oxidising agents |
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Health: H373, H361, H318 | |||
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Not listed (Not listed) | |||
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Not registered | |||
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Shelf-life for sale is 2 years but once package is opened shelf-life reduces to 6 months. Store in a refrigerator (2-8 DegC). |
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pregabalin | ||
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Record last updated: | 22/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |