Tylvalosin tartrate |
Last updated: 08/02/2024 |
(Also known as: AIVT tartrate; AIV tartrate; acetylisovaleryltylosin tartrate) |
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A macrolide antibiotic, orally administered, veterinary drug active mainly against gram-positive bacteria | |
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Current | |
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Mainly used to control respiratory diseases such as asteurellosis, infectious pleuropneumonia and mycoplasmal pneumonia | |
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Swine; Poultry |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₅₇H₉₃NO₂₅ | |
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CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)OC(=O)C)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.C(C(C(=O)O)O)(C(=O)O)O | |
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CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)OC(=O)C)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)\C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O | |
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OLLSDNUHBJHKJS-XKORHJEPSA-N | |
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InChI=1S/C53H87NO19.C4H6O6/c1-16-38-36(26-65-52-49(64-15)48(63-14)44(60)31(7)67-52)22-28(4)17-18-37(57)29(5)23-35(19-20-55)46(30(6)39(69-34(10)56)24-41(59)70-38)73-51-45(61)43(54(12)13)47(32(8)68-51)72-42-25-53(11,62)50(33(9)66-42)71-40(58)21-27(2)3;5-1(3(7)8)2(6)4(9)10/h17-18,20,22,27,29-33,35-36,38-39,42-52,60-62H,16,19,21,23-26H2,1-15H3;1-2,5-6H,(H,7,8)(H,9,10)/b18-17+,28-22+;/t29-,30+,31-,32-,33+,35+,36-,38-,39-,42+,43-,44-,45-,46-,47-,48-,49-,50+,51+,52-,53-;1-,2-/m11/s1 | |
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Yes |
General status |
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Medicinal drug, Antibiotic, Medicated feed additive | |
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Unclassified substance | |
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Synthetic | |
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Acts by inhibiting protein synthesis in the bacterial cell | |
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[50S ribosome subunit, Binder] | |
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63428-13-7 | |
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56840638 | |
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Antibacterials for systemic use, macrolides. | |
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QJ01FA92 | |
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No | |
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1192.34 | |
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[(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6R)-6-[[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-4-acetyloxy-16-ethyl-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate;(2R,3R)-2,3-dihydroxybutanedioic aci | |
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[(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6R)-6-[[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-4-acetyloxy-16-ethyl-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate;(2R,3R)-2,3-dihydroxybutanedioic aci | |
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White to yellow coloured granular substance |
Formulations |
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Aivlosin oral powder for pigs | Eco Animal Health Ltd | Not licensed | Not licensed | ||||||
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Usually formulated as oral powders or medicated premix feeds |
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948000 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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387000 | E4 E = Manufacturers safety data sheets Methanol4 = Verified data |
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220000 | E4 E = Manufacturers safety data sheets Ethanol4 = Verified data |
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301000 | E4 E = Manufacturers safety data sheets Acetone4 = Verified data |
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77000 | E4 E = Manufacturers safety data sheets Ethyl acetate4 = Verified data |
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125 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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Degradation |
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20 | E4 E = Manufacturers safety data sheets 4 = Verified data |
Non-persistent | |||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 750 | E4 E = Manufacturers safety data sheets Mouse4 = Verified data |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 100 | E4 E = Manufacturers safety data sheets Oncorhynchus mykiss as tylvalosin4 = Verified data |
Low | ||||||||
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617 | E4 E = Manufacturers safety data sheets Daphnia magna as tylvalosin4 = Verified data |
Low | ||||||||
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General |
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> 750 | E4 E = Manufacturers safety data sheets Mouse4 = Verified data |
Moderate | ||||||||
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Pattern of use is unlikely to result in toxicological relevant exposure | |||||||||
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Pattern of use is unlikely to result in toxicological relevant exposure | ||||||||||
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Extensively metabolised with the parent drug accounting for less than 7% in both urine and faeces. Urinry and biliary elimination. | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Health issues |
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May cause respitatory issues upon exposure |
Handling issues |
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Minimise creation of dust - dust cloud may form an explosive mixture with air | |||
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Health: H335, H319, H315 | |||
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Not listed (Not listed) | |||
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Not registered | |||
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Packaged product has a 3 yr shelf-life but once opened product should be used immediately. Do not store opened bags. |
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tylvalosin tartrate | ||
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Record last updated: | 08/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |