Phenobarbital |
![]() Last updated: 16/09/2025 |
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(Also known as: phenobarbitone; phenylethylbarbiturate; fenobarbitol) |
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A barbiturate anticonvulsant veterinary drug | |
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Mainly used to treat seizure, as a sedative and as an antianxiety medication | |
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Cats; Dogs; Ferrets; Horses; Sheep |
Approval status |
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Approved - usually supplied as a prescription only medicine to be authorised by a veterinarian (POM-V) | |
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Approved |
Chemical structure |
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None | |
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C₁₂H₁₂N₂O₃ | |
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CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2 | |
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DDBREPKUVSBGFI-UHFFFAOYSA-N | |
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InChI=1S/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17) | |
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Yes |
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Common Name | Relationship | Link |
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phenobarbital | - | ![]() |
General status |
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Barbiturate; Anticonvulsant | |
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Barbiturate | |
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Synthetic | |
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A nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. | |
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[Gamma-aminobutyric acid receptor subunit alpha-1, Potentiator], [Neuronal acetylcholine receptor subunit alpha-4, Antagonist], [Neuronal acetylcholine receptor subunit alpha-7, Antagonist], [Glutamate receptor 2, Antagonist], [Glutamate receptor ionotropic, kainate 2, Antagonist], [NMDA receptor, Antagonist], [Nuclear receptor subfamily 1 group I member 2, Activator] | |
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50-06-6 | |
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200-007-0 | |
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4763 | |
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Antiepileptics, Barbiturates and derivatives | |
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QN03AA02 | |
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UK: Class B, Schedule 3; EU: UN71, Class IV | |
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232.23 | |
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5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione | |
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5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione | |
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White crystalline powder |
Commercial |
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Current | |||
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1911, first synthesised | |||
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Available in a range of formulations including liquids for adding to feed and tablets for oral use | |||
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Phenobarbital is synthesised through a multi-step chemical process that begins with the preparation of key intermediates. One common route starts with benzoic acid and formic acid, which are condensed to form methyl phenylacetate. This intermediate is then reacted with thionyl chloride to produce phenylacetyl chloride, a reactive acyl compound. Next, phenylacetyl chloride is combined with isovaleryl urea under basic conditions to yield 5-phenyl-5-isovaleric acid, a precursor to the barbiturate ring. In the final step, this compound is reacted with ethanolamine in the presence of sodium hydroxide under reflux, forming the phenobarbital molecule. The product is then purified through acidification, solvent extraction, and distillation. | |||
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GHG emissions are estimated to be 20–40 kg CO₂e per kg of phenobarbital, assuming standard industrial practices and solvent recovery systems. |
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34.8 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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174 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.95 X 1001 | Calculated | - | |||||||
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1.47 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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7.3 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.557 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Substance may enter the environment via the faeces of treated animals |
Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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162 | E4 E = Manufacturers safety data sheets Rat4 = Verified data |
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Aquatic ecotoxicology |
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484 | E4 E = Manufacturers safety data sheets Pimephales promelas4 = Verified data |
Low | ||||||||
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1460 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
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General |
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162 | E4 E = Manufacturers safety data sheets Rat4 = Verified data |
Moderate | ||||||||
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Pattern of use is unlikely to result in toxicological relevant exposure | |||||||||
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Pattern of use is unlikely to result in toxicological relevant exposure | ||||||||||
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Eliminated mainly via kidney and faeces | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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CLP data - suspected carcinogen |
Handling issues |
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Combustible Incompatible with strong oxidising substances |
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Health: H360, H351, H317, H201 | |||
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Not listed (Not listed) | |||
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UN2811 | |||
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Sensitive to prolonged exposure to light. Aqueous solutions are unstable. |
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phenobarbital | ||
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Record last updated: | 16/09/2025 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |