Spironolactone |
Last updated: 28/05/2024 |
(Also known as: aldactone; spiroctan) |
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A diuretic drug used to treat fluid retention caused by chronic diseases. There is some evidence to suggest spironolactone is a prodrug. | |
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Current | |
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1957, discovered; 1959, introduced to the market | |
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Treats fluid retention due to heart failure, kidney disease and other chronic issues. Spironolactone acts both as a diuretic and as an antihypertensive agent. | |
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Cats; Dogs |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₄H₃₂O₄S | |
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CC(=O)SC1CC2=CC(=O)CCC2(C3C1C4CCC5(C4(CC3)C)CCC(=O)O5)C | |
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CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C | |
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LXMSZDCAJNLERA-ZHYRCANASA-N | |
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InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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spironolactone | - | |
spironolactone ethyl acetate | Variant |
General status |
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Medicinal drug | |
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Sterol lactone drug | |
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Synthetic | |
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Aldosterone antagonist. It inhibits aldosterone at the mineral corticord receptor of target cells in distal renal tubes | |
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[Aldosterone, Antagonist] | |
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52-01-7 | |
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496916-40-6 | |
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200-133-6 | |
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5833 | |
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Cardiovascular system: Diuretics, Aldosterone agents | |
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QC03DA01 | |
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No | |
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416.6 | |
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S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate | |
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S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate | |
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Environmental contaminant | |
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Cream to light brown coloured crystalline solid |
Formulations |
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Cardalis 10 tablets for dogs | Ceva Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Prilactone chewable tablets | Ceva Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated in tablet form |
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22.0 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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134 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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6.03 X 1002 | Calculated | - | |||||||
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2.78 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderate | ||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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Metabolised in the liver to canrenone & other active metabolites. Eliminated in urine. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause drowsiness and mental confusion CLP data - suspected of causing cancer |
Handling issues |
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Will emit toxic fumes if heated to decomposition | |||
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Health: H351, H360F, H373 | |||
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Not listed (Not listed) | |||
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spironolactone | ||
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Record last updated: | 28/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |