Buserelin acetate |
![]() Last updated: 13/09/2025 |
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(Also known as: etilamide acetate) |
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A synthetic hormone veterinary drug used to treat decreased fertility | |
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Mainly used to treat decreased fertility by ovarian dysfunction | |
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Cattle; Horses; Rabbits & other small mammals; Trout |
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Approved - usually supplied as a prescription only medicine to be authorised by a veterinarian (POM-V) | |
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Approved |
Chemical structure |
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Buserelin acetate exhibits stereoisomerism, specifically optical isomerism, due to the presence of multiple chiral centres in its peptide structure. As a synthetic analog of gonadotropin-releasing hormone, buserelin contains a sequence of amino acids, some of which are L-isomers and others D-isomers, such as D-serine, strategically arranged to enhance receptor binding and metabolic stability. | |
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C₆₂H₉₀N₁₆O₁₅ | |
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CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6.CC(=O)O | |
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CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6.CC(=O)O | |
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PYMDEDHDQYLBRT-DRIHCAFSSA-N | |
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InChI=1S/C60H86N16O13.C2H4O2/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40;1-2(3)4/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65);1H3,(H,3,4)/t40-,41-,42-,43-,44-,45-,46-,47+,48-;/m0./s1 | |
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Yes |
General status |
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Medicinal drug, Fertility Treatment | |
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Synthetic hormone | |
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Synthetic | |
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Gonadotropin-releasing hormone agonist | |
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[Lutropin-choriogonadotropic hormone receptor], [Gonadotropin-releasing hormone receptor] | |
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68630-75-1 | |
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636-185-5 | |
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50224 | |
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Systemic hormone preparations excluding sex hormones & insulins: Pituitary and hypothalamic hormones and analogues | |
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QH01CA90 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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1299.5 | |
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acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide | |
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Commercial |
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Current | |||
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1976, first described; 1984, introduced for medical use | |||
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Usually supplied as a solution for injection | |||
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Buserelin acetate is produced through a liquid-phase peptide synthesis method that carefully assembles its nine amino acid sequence. The process begins by synthesszing two key fragments: a tetrapeptide (pGlu-His-Trp-Ser-OH) and a pentapeptide (Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt), each built using protected amino acids to control reactivity and stereochemistry. These fragments are then condensed in solution, forming the full nonapeptide chain. Following condensation, the crude peptide undergoes precipitation, purification, desalting, and finally salt conversion to yield buserelin acetate. | |||
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Published GHG data is not available for most pharmaceuticals. However, according to industry, global averages suggest producing 1 kg of a typical active pharmaceutical ingredient can range from 10 to 100 kg CO₂e for small molecule drugs and potentially up to 1000 kg CO₂e for complex biologicals such as vaccines, depending on the drug type, its formulation, complexity of synthesis, solvent recovery, and energy sources used. |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Known metabolites |
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Terrestrial ecotoxicology |
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General |
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In humans some metablism occurs but ~50% excreted unchanged in unrine. In animals mainly metablised excreted in urine and bile | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Positive reproduction effects |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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buserelin acetate | ||
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Record last updated: | 13/09/2025 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |