Levothyroxine sodium |
Last updated: 22/05/2024 |
(Also known as: L-thyroxine sodium) |
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A synthetic thyroid hormone replacement compound used in veterinary medicine | |
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Current | |
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Used to treat hypothyroidism (low thyroid hormone) and to prevent growth of goiters | |
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Dogs; Cats |
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Approved | |
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Approved |
Chemical structure |
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Levethyroxine is the S-isomer of thyroxine | |
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C₁₅H₁₂I₄NNaO₅ | |
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C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)[O-])N.O.[Na+] | |
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C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)[O-])N.O.[Na+] | |
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ANMYAHDLKVNJJO-LTCKWSDVSA-M | |
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InChI=1S/C15H11I4NO4.Na.H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;1H2/q;+1;/p-1/t12-;;/m0../s1 | |
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Common Name | Relationship | Link |
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levothyroxine sodium monohydrate | Hydrate |
General status |
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Medicinal drug: synthetic thyroxime | |
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Synthetic hormone | |
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Synthetic | |
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Acts as endogenous thyroxine, stimulating metabolism, growth, development and differentiation of tissues | |
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[Thyroid hormone receptor alpha, Agonist], [Thyroid hormone receptor beta, Agonist] | |
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25416-65-3 | |
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55-03-8 | |
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200-221-4 | |
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23667619 | |
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Synthetic thyroid hormones: Thyroid hormones | |
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QH03AA01 | |
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816.87 | |
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sodium;(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate;hydrate | |
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Formulations |
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Soloxine Tablets | Virbac | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Thyforon Flavoured Tablets | Eurovet Animal Health B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Thyroxanil Tablets | Le Vet Beheer B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated as tablets for oral administration |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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> 20 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Aquatic ecotoxicology |
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General |
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> 20 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Metabolised mainly in liver & kidneys, eliminated via the faeces and urine | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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Blood toxicant High doses may induce thyrotoxicosis which may cause weight loss, increased appetite, palpitations, nervousness, diarrhoea, abdominal cramps as well as other symptoms |
Handling issues |
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Will emit toxic fumes when heated to decomposition | |||
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Not listed (Not listed) | |||
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None allocated | |||
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levothyroxine sodium | ||
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Record last updated: | 22/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |