Neomycin sulphate |
Last updated: 08/02/2024 |
(Also known as: neomycsin sulfate; framycetin sulfate; framycetin sulphate) |
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A broad spectrum antibiotic effective against a wide range of bacteria | |
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Current | |
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1949, discovered | |
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Used to treat bacterial gastrointestinal infections and mastitis | |
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Cats; Dogs; Fish; Cattle; Pigs; Sheep; Poultry |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₃H₄₈N₆O₁₇S | |
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C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O | |
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C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O | |
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OIXVKQDWLFHVGR-WQDIDPJDSA-N | |
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InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1 | |
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Yes |
General status |
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Medicinal drug, Antibiotic, Antibacterial | |
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Aminoglycoside | |
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Natural | |
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Inhibits bacteria by suppressing protein synthesis and growth. | |
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[30S ribosomal protein S12, Antagonist], [16S rRNA, Antagonist] | |
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1405-10-3 | |
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4146-30-9 | |
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215-773-1 | |
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197162 | |
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Alimentary tract & metabolism: Intestinal anti-infectants | |
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QA07AA51 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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712.7 | |
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(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid | |
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Formulations |
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Multiject IMM Intramammary Suspension | Norbrook Laboratories Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Multishield Intramammary Suspension | Bimeda Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available as solutions for intramammary injections. For poultry the substance is often formuated as a drinking water additive |
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Neomycin enters the environment mainly via the faeces of treated animals |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 200 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 200 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Up to 97% of oral dose excreted unchanged in faeces | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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Health issues |
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Kidney toxicant May cause dermatitis May impair hearing or cause vertigo |
Handling issues |
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When heated to decomposition it emits acrid smoke & irritating fumes | |||
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Not listed (Not listed) | |||
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neomycin sulphate | ||
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Record last updated: | 08/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |