Amitriptyline hydrochloride |
Last updated: 09/02/2024 |
(Not known by any other names) |
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Amitriptyline is a tricyclic antidepressant | |
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Current | |
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1960, discovered | |
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Used to treat many behavioral disorders in pets such as excessive grooming and urine spraying | |
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Cats; Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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- | |
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C₂₀H₂₄ClN | |
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CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl | |
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KFYRPLNVJVHZGT-UHFFFAOYSA-N | |
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InChI=1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H | |
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Yes |
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Common Name | Relationship | Link |
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amitriptyline hydrochloride | - |
General status |
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Medicinal drug: Tricyclic antidepressant | |
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Unclassified substance | |
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Synthetic | |
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Acts via the inhibition of serotonin and other transmitters at presynaptic nerve terminals. | |
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[Sodium-dependent noradrenaline transporter, Inhibitor], [Sodium-dependent serotonin transporter, Inhibitor], [ 5-hydroxytryptamine receptor 2A, Antagonist], [5-hydroxytryptamine receptor 1A, Inhibitor] | |
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549-18-8 | |
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208-964-6 | |
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11065 | |
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Antidepressants in combination with psycholeptics: Amitriptyline and psycholeptics | |
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QN06CA01 | |
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No | |
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313.9 | |
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N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine;hydrochloride | |
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White powdery solid | |
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Formulations |
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10.84 | Q3 Q = Miscellaneous data from online sources at 25 °C3 = Unverified data of known source |
Low | ||||||||
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198 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.00 X 1005 | Calculated | - | |||||||
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5.0 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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240 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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0.25 | E4 E = Manufacturers safety data sheets Oncorhynchus mykiss 4 = Verified data |
Moderate | ||||||||
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> 1.6 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio4 = Verified data |
Moderate | ||||||||
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> 3.43 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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1.69 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lemna minor4 = Verified data |
Moderate | ||||||||
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0.16 | E4 E = Manufacturers safety data sheets Selenastrum capricornutum4 = Verified data |
Moderate | ||||||||
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General |
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240 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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Metabolised in the liver and eliminated in the urine with around 18% as the unchanged drug. Small amounts lost in bile and excreted in maternal milk in humans. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May lower blood pressure and cause drowsiness CNS toxicant May cause gastrointestinal changes |
Handling issues |
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Incompatible with strong oxidising agents IMDG Transport Hazard Class 6.1 |
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Health: H301, H319, H361d Environment: H400, H410 |
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging group III (minor danger) | |||
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Chemically stable under standard ambient conditions |
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amitriptyline hydrochloride | ||
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Record last updated: | 09/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |