Megestrol acetate |
Last updated: 28/05/2024 |
(Also known as: megestrol; MGA) |
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A potent synthetic derivative of progesterone with veterinary applications | |
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Current | |
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1992, first registrations | |
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The main application is to postpone estrus and to relieve the effects of false pregnancy. It also has uses to treat benign prostatic hypertrophy in male dogs aas well as skin and behavior conditions in cats. | |
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Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₄h₃₂O₄ | |
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CC1=CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C | |
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CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C | |
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RQZAXGRLVPAYTJ-GQFGMJRRSA-N | |
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InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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megestrol acetate | - | |
megestrol acetate | - |
General status |
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Medicinal drug | |
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A synthetic progestin hormone | |
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Synthetic | |
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Appears to have multiple mechanisms including as an agonist of the progesterone receptor and as an appetite stimulant | |
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[Progesterone receptor, Agonist], [Proinflammatory cytokines, Inhibitor] | |
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595-33-5 | |
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209-864-5 | |
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11683 | |
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Hormonal contraceptions for systemic use: Progestogens | |
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QG03AC05 | |
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No | |
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384,5 | |
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[(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate | |
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Identified in surface and marinen waters | |
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Whit powdery solid |
Formulations |
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Ovarid Tablets | Virbac | UK Nstional authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Mainly administered via the oral route |
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2.0 | H3 H = The US ARS pesticide properties database. Dataset is no longer available. 3 = Unverified data of known source |
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218 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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1.58 X 1003 | Calculated | - | |||||||
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3.2 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Degradation |
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6.3 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Literature data suggests rapid degradation DT₅₀ 110-191 hrs | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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1.99 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Unknown species3 = Unverified data of known source |
Moderate | ||||||||
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0.0471 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
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1.81 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Green algae3 = Unverified data of known source |
Moderate | ||||||||
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General |
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Intravenous LD₅₀ = 56.0 mg kg⁻¹ | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse3 = Unverified data of known source |
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Majority of the administered dose is lost via urine | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Health issues |
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Harrmful via consumprion, inhalation and in contact with the skin, CLP data - suspected carcinogen; US EPA - probable human carcinogen Links identified with osteoporosis |
Handling issues |
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IMDG Transport Hazard Class 9 | |||
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Health: H302, H312, H332, H341, H351, H373 Environment: H413 |
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UN3077 | |||
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Packaging group III (minor danger) | |||
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megestrol acetate | ||
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Record last updated: | 28/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |