Flunixin meglumine |
Last updated: 22/05/2024 |
(Also known as: banamine; Sch 14714 meglumine) |
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A non-steroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in veterinary medicine | |
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Current | |
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circa 1990s, introduced | |
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Mainly used to treat skeletal and muscular disorders as well as colic | |
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Horses; Cattle; Pigs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₁H₂₈F₃N₃O₇ | |
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CC1=C(C=CC=C1NC2=C(C=CC=N2)C(=O)O)C(F)(F)F.CNCC(C(C(C(CO)O)O)O)O | |
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CC1=C(C=CC=C1NC2=C(C=CC=N2)C(=O)O)C(F)(F)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O | |
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MGCCHNLNRBULBU-WZTVWXICSA-N | |
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InChI=1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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flunixin | Parent | |
flunixin meglumine | - |
General status |
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Anagelsic, anti-inflammatory, Medicinal drug | |
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Unclassified substance | |
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Synthetic | |
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Works via the inhibition of cyclooxygenase, blocks synthesis of eicosanoids which are chemical mediators of inflammation | |
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[Prostaglandin G/H Synthase 2, Antagonist] | |
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42461-84-7 | |
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255-836-0 | |
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39212 | |
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Musculo-skeletal system: Anti-inflammatory & antirheumatic products | |
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QM01AG90 | |
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No | |
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Allowed substance (Table 1: Bovine, Porcine, Equidae) | |
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491.5 | |
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(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol;2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid | |
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Clear liquid | |
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Formulations |
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Cronyxin 5% w/v Solution for Injection | Bimeda Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Emdofluxin Solution for Injection | Emdoka | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Flovuxin Solution for Injection | Krka d.d. Novo Mestro | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Resflor Solution for Injection | MSD Animal Health Uk Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available in a variety of formulations including solutions for injection, pour-on products and oral pastes |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 53 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
High | ||||||||
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375 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Colinus virginianus4 = Verified data |
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Aquatic ecotoxicology |
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> 46 | E4 E = Manufacturers safety data sheets Lepomis macrochirus4 = Verified data |
Moderate | ||||||||
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25.0 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
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> 36 | E3 E = Manufacturers safety data sheets Unknown speciies3 = Unverified data of known source |
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General |
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High (class III) | - | - | ||||||||
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> 53 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Widely distributed throughout body tissues and fluids. Excretion via urine, bile and other gastrointestinal secretions. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause gastrointestinal problems Possible liver and kidney toxicant |
Handling issues |
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IMDG Transport Hazard Class 6.1 Inccompatible with acids, bases, and oxidising agents |
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Health: H302, H315, H318, H333, H373 Environment: H412 |
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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flunixin meglumine | ||
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Record last updated: | 22/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |