Flunixin meglumine |
![]() Last updated: 14/09/2025 |
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(Also known as: banamine; Sch 14714 meglumine) |
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A non-steroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in veterinary medicine | |
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Mainly used to treat skeletal and muscular disorders as well as colic | |
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Horses; Cattle; Pigs |
Approval status |
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Approved - usually supplied as a prescription only medicine to be authorised by a veterinarian (POM-V) | |
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Approved |
Chemical structure |
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Flunixin meglumine exhibits stereoisomerism, specifically chirality, due to the presence of multiple chiral centres in its meglumine component. The active compound, flunixin, is a nonsteroidal anti-inflammatory drug with a relatively simple aromatic structure that itself is achiral. However, when flunixin is formulated as the meglumine salt, it is paired with meglumine (N-methylglucamine), a sugar alcohol derivative that contains five chiral centres at positions C2 through C6 of the hexane backbone. These centres are configured as (2R,3R,4R,5S) in the pharmaceutical-grade compound, giving the meglumine portion a defined stereochemistry that influences solubility, stability, and pharmacokinetics. | |
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C₂₁H₂₈F₃N₃O₇ | |
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CC1=C(C=CC=C1NC2=C(C=CC=N2)C(=O)O)C(F)(F)F.CNCC(C(C(C(CO)O)O)O)O | |
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CC1=C(C=CC=C1NC2=C(C=CC=N2)C(=O)O)C(F)(F)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O | |
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MGCCHNLNRBULBU-WZTVWXICSA-N | |
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InChI=1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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flunixin | Parent | ![]() |
flunixin meglumine | - | ![]() |
General status |
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Anagelsic, anti-inflammatory, Medicinal drug | |
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Unclassified substance | |
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Synthetic | |
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Works via the inhibition of cyclooxygenase, blocks synthesis of eicosanoids which are chemical mediators of inflammation | |
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[Prostaglandin G/H Synthase 2, Antagonist] | |
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42461-84-7 | |
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255-836-0 | |
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39212 | |
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Musculo-skeletal system: Anti-inflammatory & antirheumatic products | |
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QM01AG90 | |
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No | |
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Allowed substance (Table 1: Bovine, Porcine, Equidae) | |
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491.5 | |
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(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol;2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid | |
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Clear liquid | |
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Commercial |
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Current | |||
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Circa 1990s, introduced | |||
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Usually supplied as a solution for injection or as a powder for preparation as a solution for injection | |||
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Flunixin meglumine is produced through a two-stage synthesis beginning with the formation of flunixin, a nonsteroidal anti-inflammatory compound. The process starts by reacting 2-chloronicotinic acid with 2-methyl-3-trifluoromethylaniline in an aqueous sodium hydroxide solution, often with a phase-transfer catalyst and an organic solvent like toluene. This mixture is stirred and heated at around 40–45 DegC for several hours, forming flunixin via nucleophilic aromatic substitution. After adjusting the pH and isolating the product through filtration and drying, the crude flunixin is then reacted with N-methylglucamine (meglumine) in isopropanol under reflux conditions for 0.5–1.5 hours. The resulting flunixin meglumine salt is then crystallised. | |||
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Published GHG data is not available for most pharmaceuticals. However, according to industry, global averages suggest producing 1 kg of a typical active pharmaceutical ingredient can range from 10 to 100 kg CO₂e for small molecule drugs and potentially up to 1000 kg CO₂e for complex biologicals such as vaccines, depending on the drug type, its formulation, complexity of synthesis, solvent recovery, and energy sources used. |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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> 53 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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375 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Colinus virginianus4 = Verified data |
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Aquatic ecotoxicology |
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> 46 | E4 E = Manufacturers safety data sheets Lepomis macrochirus4 = Verified data |
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25.0 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
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> 36 | E3 E = Manufacturers safety data sheets Unknown species3 = Unverified data of known source |
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General |
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High (class III) | - | - | ||||||||
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> 53 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Widely distributed throughout body tissues and fluids. Excretion via urine, bile and other gastrointestinal secretions. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause gastrointestinal problems Possible liver and kidney toxicant |
Handling issues |
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IMDG Transport Hazard Class 6.1 Inccompatible with acids, bases, and oxidising agents |
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Health: H302, H315, H318, H333, H373 Environment: H412 |
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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flunixin meglumine | ||
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Record last updated: | 14/09/2025 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |