Cyproterone acetate |
Last updated: 28/05/2024 |
(Also known as: CPA; cyproterone 17-O-acetate) |
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A 17-hydroxyprogesterone acetate derivative with strong progestagenic properties and which has veterinary applications | |
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Current | |
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Used for the treatment of benign prostatic hyperplasia and reducing aggressive or antisocial behaviour | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₂₄H₂₉ClO₄ | |
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[H][C@@]12C[C@]1([H])[C@@]1(C)C(=CC2=O)C(Cl)=C[C@@]2([H])[C@]3([H])CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@]12[H] | |
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UWFYSQMTEOIJJG-FDTZYFLXSA-N | |
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InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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cyproterone acetate | - | |
cyproterone | Parent |
General status |
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Medininal drug | |
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Pregnane steroid | |
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Synthetic | |
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It suppresses the actions of testosterone (and its metabolite dihydrotestosterone) on tissues | |
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[Androgen receptor, Antagonist], [Prostate-specific antigens] | |
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427-51-0 | |
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207-048-3 | |
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9880 | |
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Genito urinary system and sex hormones | |
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G03HA01 | |
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No | |
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416.94 | |
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(1S,2S,3S,5R,11R,12S,15R,16S)-15-acetyl-9-chloro-2,16-dimethyl-6-oxopentacyclo[9.7.0.0^{2,8}.0^{3,5}.0^{12,16}]octadeca-7,9-dien-15-yl acetate | |
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Solid |
Formulations |
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50000 | E3 E = Manufacturers safety data sheets Methanol3 = Unverified data of known source |
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10000 | E3 E = Manufacturers safety data sheets Ethanol3 = Unverified data of known source |
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83000 | E3 E = Manufacturers safety data sheets DMSO3 = Unverified data of known source |
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200 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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1.26 X 1003 | Calculated | - | |||||||
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3.1 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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7 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-persistent | |||||||
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Literature gives soil DT₅₀ as 135-217 hours depending on soil type | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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15beta-hydroxycyproterone acetate | - | Humans (Liver) | - |
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Terrestrial ecotoxicology |
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> 5000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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0.16 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Pimephales promelas4 = Verified data |
Moderate | ||||||||
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2.1 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 5000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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Excreted around 60% in the bile and 33% through the kidneys. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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CLP data: suspected carcinogen |
Handling issues |
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Incompatible with trong oxidising agents Avoid generation of dusts |
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Health: H312, H332, H351, H360, H373 | |||
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Not listed (Not listed) | |||
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Not regulated | |||
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cyproterone acetate | ||
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Record last updated: | 28/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |