Estradiol |
Last updated: 22/05/2024 |
(Also known as: oestradiol; 17beta oestradiol; beta-estradiol) |
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A semisynthetic estrogenic hormone with veterinary applications | |
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Current | |
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- | |
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Mainly used as a hormone replacement therapy in conditions of inadequate estrogen production | |
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Horses; Cattle; Cats; Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₁₈H₂₄O₂ | |
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CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O | |
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C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O | |
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VOXZDWNPVJITMN-ZBRFXRBCSA-N | |
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InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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estradiol hemihydrate | Hydrate | |
estradiol | - | |
ethinyl estradiol | Variant |
General status |
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Medicinal drug; Hormone | |
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Steroid hormone | |
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Semi-synthetic | |
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Substance binds to its specific intracellular receptor and regulates DNA transcription for protein formation | |
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[Estrogen receptor alpha, Agonist], [Estrogen receptor beta, Agonist], [Beclin-1, Binder], [ATP synthase subunit a, Inhibitor], [Nuclear receptor subfamily 1 group I member 2, Binder], [Neuronal acetylcholine receptor subunit alpha-4, Binder], [G-protein coupled estrogen receptor 1, Binder] | |
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17916-67-5 | |
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200-023-8 | |
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5757 | |
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Estrogens: Natural and semisynthetic estrogens, plain | |
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QG03CA03 | |
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No | |
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- | |
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272.4 | |
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- | |
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(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol | |
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3,17β-dihydroxy-1,3,5(10)-estratriene | |
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- | |
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White crystalline solid | |
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Formulations |
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3.6 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Low | ||||||||
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173 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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445.9 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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1.02 X 1004 | Calculated | - | |||||||
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4.01 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
High | ||||||||
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1.2 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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10.46 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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960 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 0.139 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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> 2.48 | E3 E = Manufacturers safety data sheets Desmodesmus subspicatus3 = Unverified data of known source |
Moderate | ||||||||
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General |
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960 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Moderate | ||||||||
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Health issues |
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CPL data: suspected of causing cancer |
Handling issues |
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May emit acrid smoke and irritating fumes if heated to decomposition IMDG Transport Hazard Class 9 |
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Health: H351, H360fd, H362 Environment: H410 |
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Not listed (Not listed) | |||
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UN3077 | |||
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Packaging group III (minor danger) | |||
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Chemically stable under standard ambient conditions |
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estradiol | ||
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Record last updated: | 22/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |