Colistimethate sodium |
Last updated: 01/02/2024 |
(Also known as: colimycin; colimyscine) |
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A broad-spectrum polymyxin antibiotic active against most aerobic gram-negative bacteria | |
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Current | |
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1995, first used in human medicine | |
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Used for the treatment of colibacillosis in chicks | |
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Chickens |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₅₈H₁₀₅N₁₆Na₅O₂₈S₅ | |
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[Na+].[Na+].[Na+].[Na+].[Na+].CCC(C)CCCCC(=O)NC(CCNCS([O-])(=O)=O)C(=O)NC(C(C)O)C(=O)NC(CCNCS([O-])(=O)=O)C(=O)NC1CCNC(=O)C(NC(=O)C(CCNCS([O-])(=O)=O)NC(=O)C(CCNCS([O-])(=O)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCNCS([O-])(=O)=O)NC1=O)C(C)O | |
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QWHCHZFYPIVRV-UHFFFAOYSA-I | |
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InChI=1S/C58H110N16O28S5.5Na/c1-9-35(6)12-10-11-13-46(77)65-38(14-20-59-28-103(88,89)90)53(82)74-48(37(8)76)58(87)70-41(17-23-62-31-106(97,98)99)50(79)68-43-19-25-64-57(86)47(36(7)75)73-54(83)42(18-24-63-32-107(100,101)102)67-49(78)39(15-21-60-29-104(91,92)93)69-55(84)44(26-33(2)3)72-56(85)45(27-34(4)5)71-52(81)40(66-51(43)80)16-22-61-30-105(94,95)96;;;;;/h33-45,47-48,59-63,75-76H,9-32H2,1-8H3,(H,64,86)(H,65,77)(H,66,80)(H,67,78)(H,68,79)(H,69,84)(H,70,87)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,88,89,90)(H,91,92,93)(H,94,95,96)(H,97,98,99)(H,100,101,102);;;;;/q;5*+1/p-5 | |
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Yes |
General status |
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Medicinal drug | |
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Cyclic polypeptide | |
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Snythetic | |
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Disrupts the bacterial cell membrane | |
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[Lipid A, Binder] | |
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8068-28-8 | |
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532-516-9 | |
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7849111 | |
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Antiinfectives and/or antiseptics, combinations for intrauterine use: Ampicillin and colistin | |
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QG51AG07 | |
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No | |
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1749.81 | |
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pentasodium [(3-{3-hydroxy-2-[2-(6-methyloctanamido)-4-[(sulfonatomethyl)amino]butanamido]butanamido}-3-{[3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris({2-[(sulfonatomethyl)amino]ethyl})-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)amino]methanesulfonate | |
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Fine white powder | |
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Formulations |
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Usually formulated as a solution for injection |
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450000 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.00 X 1001 | Calculated | - | |||||||
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1.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Kow <103 = Unverified data of known source |
Low | ||||||||
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11.53 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) colistin3 = Unverified data of known source |
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The major route of introduction of colistin to the environment is via faecal matter and manure from treated birds |
Degradation |
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21.5 | R3 R = Peer reviewed scientific publications as colistin3 = Unverified data of known source |
Non-persistent | |||||||
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Literature suggests DT₅₀ range 13.2-29.7 days | ||||||||||
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10 | F2 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Data suggests that total colistin in soil/manure would be mineralised within 21 days2 = Unverified data of unknown source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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8306 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Non-mobile | |||||||
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652913 | ||||||||||
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USEPA data: Kd range 4452-11583 mL g⁻¹, Koc range 545647-866183 mL g⁻¹, Soils=3; Chicken manure Kd=519 mL g⁻¹, Koc=1472 mL g⁻¹ | ||||||||||
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Fate indices |
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-2.42 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Known soil and groundwater metabolites |
None
Other known metabolites |
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colistin | - | Chicken | 1.00 |
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Terrestrial ecotoxicology |
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> 5000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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> 5000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
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Colistimethate sodium is completely metabolised to colistin prior to excretion | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Health issues |
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May irritate gastic function |
Handling issues |
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No information available | |||
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Health: H361, H362 | |||
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Not listed (Not listed) | |||
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Not registered | |||
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Store at 20-25 DegC and protect from light |
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colistimethate sodium | ||
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Record last updated: | 01/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |