Melengestrol acetate |
Last updated: 28/05/2024 |
(Also known as: MGA) |
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Melengestrol Acetate is a progestogen-like compound used as a feed additive | |
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1996, first approvals USA | |
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Used for growth promotion and suppression of estrus (heat | |
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Cattle |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₂₅H₃₂O₄ | |
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CC1=CC2C(CCC3(C2CC(=C)C3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C | |
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CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC(=C)[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C | |
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UDKABVSQKJNZBH-DWNQPYOZSA-N | |
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InChI=1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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melengestrol acetate | - |
General status |
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Medical drug, Feed additive | |
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Steroid; Synthetic progestin | |
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Synthetic | |
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Progestins generally work by suppressing the secretion of GnRH, LH) and FSH by the pituitary gland. This suppression alters the menstrual cycle to suppress ovulation. | |
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[Gonadotropin-releasing hormone (GnRH), Antagonist], [Luteinizing hormone (LH), Antagonist], [Follicle-stimulating hormone (FSH) , Antagonist] | |
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2919-66-6 | |
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220-859-7 | |
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250948 | |
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Genito urinary system and sex hormones; Progestogens | |
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QG03DB91 | |
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No | |
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396.53 | |
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[(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-16-methylidene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl] acetate | |
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Off-white to pale yellow coloured powdery solid |
Formulations |
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Usually formulated as a medicated pre-mix feed |
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1.06 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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224 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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9.55 X 1003 | Calculated | - | |||||||
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3.98 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Substance may enter the environment via the urine of treated animals or by leaching from spilt medicated feed. |
Degradation |
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12.5 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-persistent | ||||||||
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- | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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USEPA data: Lab studies DT₅₀ range 4.3-27.8 days, Soils=3 | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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779 | F2 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 2 = Unverified data of unknown source |
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USEAPA: Kd range 549-1009 mL g⁻¹ | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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2alpha-hydroxy-melengestrol acetate | - | Mammals | - | ||||
6-hydroxymethyl-melengestrol acetate | - | Mammals | - |
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Terrestrial ecotoxicology |
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> 8000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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> 2.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lumbricus terrestris3 = Unverified data of known source |
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>= 2.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lumbricus terrestris3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 1.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Carassius auratus3 = Unverified data of known source |
Moderate | ||||||||
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>= 2.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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>= 2.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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General |
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> 8000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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22 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ > 2500 mg kg⁻¹ | E3 E = Manufacturers safety data sheets Mouse3 = Unverified data of known source |
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Subcutaneous LD₅₀ > 5000 mg kg⁻¹ | E3 E = Manufacturers safety data sheets Mouse3 = Unverified data of known source |
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Extensively metabolised and mainly excreted in urine | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Health issues |
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No information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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melengestrol acetate | ||
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Record last updated: | 28/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |