Zilpaterol hydrochloride (Ref: RU 42173) |
Last updated: 20/03/2024 |
(Also known as: zilpaterol HCl; RU 41173) |
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A synthetic beta2-adrenoreceptor agonist | |
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Current | |
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Used to improve growth and feeding efficiency | |
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Cattle |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Zilpaterol has two chiral carbons and consequently four optical enantiomers. Commercial product is usually a racemic trans-zilpaterol HCl, a mixture of the (6R,7R) and (6S,7S) enantiomers. | |
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C₁₄H₂₀ClN₃O₂ | |
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CC(C)NC1CCN2C3=C(C1O)C=CC=C3NC2=O.Cl | |
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CC(C)N[C@@H]1CCN2C3=C([C@H]1O)C=CC=C3NC2=O.Cl | |
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GIEFXLLRTJNFGT-LOCPCMAASA-N | |
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InChI=1S/C14H19N3O2.ClH/c1-8(2)15-11-6-7-17-12-9(13(11)18)4-3-5-10(12)16-14(17)19;/h3-5,8,11,13,15,18H,6-7H2,1-2H3,(H,16,19);1H/t11-,13-;/m1./s1 | |
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Yes |
General status |
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Medicinal drug, Growth promotor | |
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Beta-Adrenergic agonist | |
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Synthetic | |
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A synthetic beta2-adrenoreceptor agonist that binds with the muscle beta-adrenoreceptors leading to the activation of protein kinase A, an enzyme responsible for changes in protein synthesis and degradation | |
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[Beta-2 adrenergic receptor, Agonist], [Beta-1 adrenergic receptor, Binder], [Muopiod receptor, Antagonist | |
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119520-06-8 | |
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601-619-4 | |
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11507658 | |
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Growth promotor | |
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None allocated | |
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No | |
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297.78 | |
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(9R,10R)-9-hydroxy-10-(propan-2-ylamino)-1,3-diazatricyclo[6.4.1.04,13]trideca-4,6,8(13)-trien-2-one;hydrochloride | |
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White to yellow coloured powder |
Formulations |
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Usually formulated as a mdicated feed additive or premix |
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150000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
High | ||||||||
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200 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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1.00 X 1001 | Calculated | - | |||||||
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1 | F2 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 2 = Unverified data of unknown source |
Low | ||||||||
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8.09 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Substance may enter the environment via the urine and faeces of treated animals or by leaching from spilt medicated feed. |
Degradation |
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21.5 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-persistent | ||||||||
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USEPA data: Soil DT₅₀ 17.3-24.8 days | ||||||||||
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Stable | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) No degradation seen in 126 days3 = Unverified data of known source |
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60 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Stable | |||||||
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pH sensitive: DT₅₀ 53 days at pH4, Dt50 28 days at pH9 | ||||||||||
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365 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Very persistent | |||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Slightly mobile | |||||||
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566 | ||||||||||
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Fate indices |
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1.66 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 500 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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> 500 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.04 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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0.04 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Eliminated almost completely via urine (50–55%) and faeces (40–42%) within 8 days | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May cause cardiovasuclar effects May cause tremors |
Handling issues |
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No information available | |||
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Health: H302, H332, H372 | |||
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Not listed (Not listed) | |||
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zilpaterol hydrochloride | ||
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Record last updated: | 20/03/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |