Penethamate hydriodide |
Last updated: 11/03/2024 |
(Also known as: ephicillin hydriodide) |
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A substance used in veterinary medicine for its antimicrobial properties | |
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Used for the treatment of mastitis in cows and bacterial infections in a range of species | |
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Cattle; Pigs; Horses; Goats & sheep |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₂H₃₂IN₃O₄S | |
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CCN(CC)CCOC(=O)C1C(SC2N1C(=O)C2NC(=O)CC3=CC=CC=C3)(C)C.I | |
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CCN(CC)CCOC(=O)[C@H]1C(S[C@H]2N1C(=O)[C@H]2NC(=O)CC3=CC=CC=C3)(C)C.I | |
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XWRCFDRXQPRCCO-FLQNVMKHSA-N | |
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InChI=1S/C22H31N3O4S.HI/c1-5-24(6-2)12-13-29-21(28)18-22(3,4)30-20-17(19(27)25(18)20)23-16(26)14-15-10-8-7-9-11-15;/h7-11,17-18,20H,5-6,12-14H2,1-4H3,(H,23,26);1H/t17-,18+,20-;/m1./s1 | |
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Yes |
General status |
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Antimicrobial | |
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Diethylaminoethyl ester of penicillin | |
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Synthetic | |
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A prodrug which converts to benzylpenicillin and so works by blocking the biosynthesis of the bacterial cell wall | |
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808-71-9 | |
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7778-19-0 | |
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212-367-6 | |
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71796 | |
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Antibacterials for systemic use; Combination of antibacterials for intramammary use | |
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QJ01CE90; QJ51RC22 | |
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No | |
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561.5 | |
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2-(diethylamino)ethyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; hydroiodide | |
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Formulations |
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Penezin Antibiotic Injection | Alleva Animal Health Ltd | Not licensed | Not licensed | ||||||
Mamyzin powder or injection | Boehringer Ingelheim Animal Health UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Multishield DC Intramammary Suspension | Bimeda Animal Health | GB National Authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually upplied as solutions for intramammary injections |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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> 2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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Subcutaneous LD₅₀ > 2000 mg kg⁻¹ | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Intraperitoneal LD₅₀ > 30 mg kg⁻¹ | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Health: H315, H317, H319, H334, H335 | |||
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Not listed (Not listed) | |||
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Shelf life of the veterinary medicinal product as packaged for sale: 5 years |
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penethamate hydriodide | ||
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Record last updated: | 11/03/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |