Chlorpheniramine maleate |
Last updated: 11/03/2024 |
(Not known by any other names) |
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An antihistamine which is used in veterinary medicine to treat acute inflammatory and allergic conditions | |
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Current | |
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Mainly used for the management of symptoms associated with upper respiratory allergies. | |
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Dogs; Cats; Horses; Ferrets; Birds |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Substance is a racemate | |
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C₂₀H₂₃ClN₂O₄ | |
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CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O | |
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CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O | |
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DBAKFASWICGISY-BTJKTKAUSA-N | |
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InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1- | |
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Yes |
General status |
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Antihistamine | |
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Alkylamine derivative | |
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Synthetic | |
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This substance binds to the histamine H1 receptor which subsequently blocks the action of endogenous histamine | |
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[Histamine H1, Antagonist], [Sodium-dependent serotonin transporter, Inhibitor], [Sodium-dependent noradrenaline transporter, Inhibitor], [Sodium-dependent dopamine transporter, Inhibitor] | |
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113-92-8 | |
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204-037-5 | |
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5281068 | |
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Antihistamines for systemic use | |
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QR06AB04 | |
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No | |
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390.9 | |
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(Z)-but-2-enedioic acid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine | |
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Odourless white crystalline powder |
Formulations |
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AVET Chlorpheniramine Maleate | AVET Health Limited Australia | Not licensed | Not licensed | ||||||
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Available in a variety of formulations including tablets and liquids for oral use and solutions for injection |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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306 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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General |
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High (class III) | - | - | ||||||||
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306 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Moderate | ||||||||
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Primarily hepatic metabolism occurs via Cytochrome P450 (CYP450) enzymes. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause drowsiness or dizziness Corrosive |
Handling issues |
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Corrosive When heated to decomposition will emit toxic fumes of chlorine and nitrogen oxides Combustible |
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Health: H301, H302, H311, H314, H318, H336, H373 | |||
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Not listed (Not listed) | |||
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chlorpheniramine maleate | ||
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Record last updated: | 11/03/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |