Flubendazole |
Last updated: 28/05/2024 |
(Not known by any other names) |
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A broad spectrum anthelmintic used in veterinary medicine | |
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Not applicable | |
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Used to treat worm infestations | |
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Poultry; Pigs; Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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None | |
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C₁₆H₁₂FN₃O₃ | |
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COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=C(C=C3)F | |
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CPEUVMUXAHMANV-UHFFFAOYSA-N | |
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InChI=1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22) | |
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Yes |
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Common Name | Relationship | Link |
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flubendazole | - |
General status |
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Anthelmintic | |
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Benzimidazole drug | |
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Binds to tubulin, a protein required for functions including nutrient uptake, thus disrupting parasite energy metabolism | |
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[Tubulin alpha-3 chain, Antagonist] | |
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31430-15-6 | |
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250-624-4 | |
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35802 | |
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Anthelmintics: Benzimidazoles and related substances | |
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QP52AC12 | |
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No | |
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313.288 | |
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methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate | |
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methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate | |
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Current | |
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White powdery solid |
Formulations |
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Alphafluben 44 mg/ml Oral Gel for Dogs | Alpha-Vet Allatgyogyaszati Kft. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Flimabo 100 mg/g Suspension for Use in Drinking Water | Krka d.d., Novo Mesto | GB National authorisation | Prescription only medicine to be authorised by a registered, qualified person (POM-VPS) | |||||||
Flubenol 5% w/w Oral Powder | Elanco Europe Ltd | UK National authorisation | Prescription only medicine to be authorised by a registered, qualified person (POM-VPS) | |||||||
Fluboral 200 mg/ml, Suspension for Use in Drinking Water | Dechra Limited | GB National authorisation | Prescription only medicine to be authorised by a registered, qualified person (POM-VPS) | |||||||
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Usually formulated as a solution for drinking water or as a medicated feed. |
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243 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Flubendazole may enter the environment via the faeces of treated animals or by leaching from spilt medicated feed |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 5000 | F5 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat5 = Verified data used for regulatory purposes |
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Aquatic ecotoxicology |
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0.204 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio as EC₅₀ Larvae4 = Verified data |
Moderate | ||||||||
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> 0.055 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
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General |
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> 5000 | F5 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat5 = Verified data used for regulatory purposes |
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Most of the applied drug is eliminated unchanged in the faeces | Q4 Q = Miscellaneous data from online sources 4 = Verified data |
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Health issues |
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No further information available |
Handling issues |
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Incompatible with oxidising agents | |||
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Not listed (Not listed) | |||
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Not regulated | |||
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flubendazole | ||
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Record last updated: | 28/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |