Dinoprost tromethamine |
Last updated: 20/03/2024 |
(Also known as: prostaglandin F2alpha; dinoprost trometamol ; PGF2 alpha THAM; prostaglandin F2 alpha tromethamine ; amoglandin) |
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The tromethamine salt of the naturally occurring prostaglandin F2 alpa substance used in veterinary medicine | |
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Used for inducing abortion and at low-doses for medically indicated induction of labour at full term | |
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Horses; Cattle; Pigs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₄H₄₅NO₈ | |
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CCCCCC(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O.C(C(CO)(CO)N)O | |
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CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O)O.C(C(CO)(CO)N)O | |
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IYGXEHDCSOYNKY-RZHHZEQLSA-N | |
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InChI=1S/C20H34O5.C4H11NO3/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25;5-4(1-6,2-7)3-8/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25);6-8H,1-3,5H2/b7-4-,13-12+;/t15-,16+,17+,18-,19+;/m0./s1 | |
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Yes |
General status |
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Abortifacient agent, Reproduction control, Medicinal drug | |
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Unclassified substance | |
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Stimulates myometrial contractions in the gravid uterus that are similar to the contractions that occur in the term uterus during labor | |
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[Prostaglandin F2-alpha receptor, Agonist], [Prostacyclin receptor, Antagonist] | |
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38562-01-5 | |
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254-002-3 | |
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5282415 | |
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Genito Urinary system & sex hormones: Other gynecologicals | |
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QG02AD | |
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No | |
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Allowed substance (Table 1: All mammalian food producing species) | |
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475.6 | |
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2-amino-2-(hydroxymethyl)propane-1,3-diol;(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid | |
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White to off-white, very hygroscopic, crystalline powder | |
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Formulations |
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Enzaprost Solution for Injection | Ceva Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Lutalyse 5 mg/ml Solution for Injection | Zoetis UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Formulated as solutions for injection |
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2.58 | v3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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30 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.45 X 1004 | Calculated | - | |||||||
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4.39 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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5.01 X 10-09 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 1170 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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Low (class I) | - | - | ||||||||
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> 1170 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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Subcutaneous LD₅₀ = 95 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intramuscular LD₅₀ = 106 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Mostly excreted in the urine, only around 5% lost via the faeces | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Large doses may cause nausea, vomiting, and diarrhoea |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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dinoprost tromethamine | ||
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dinoprosta | ||
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Record last updated: | 20/03/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |