Icaridin (Ref: KBR 3023) |
Last updated: 21/08/2024 |
(Also known as: icaradine; picaradin; propidine; autan; hydroethyl isobutyl piperidine carboxylate) |
SUMMARY |
Icaridin is an insect repellent. It has a high aquatic solubility and is volatile. Data is limited regarding its environmental persistence. It has a relatively low mammalian toxicity and a high potential to bioaccumulate. It is not highly toxic to birds or fish. There are gaps in ecotoxicology and environmental fate data. |
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An insect repellant used for both human and animal applications to control a broad spectrum of insect pests | |
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Current | |
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2001, first registered USA; 1998, first available Europe | |
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Used topically as a repellent for general insect pests such as flies, mites, lice and fleas | |
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Livestock |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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A molecule with 2 chiral centres | |
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C₁₂H₂₃NO₃ | |
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CCC(C)OC(=O)N1CCCCC1CCO | |
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- | |
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QLHULAHOXSSASE-UHFFFAOYSA-N | |
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InChI=1S/C12H23NO3/c1-3-10(2)16-12(15)13-8-5-4-6-11(13)7-9-14/h10-11,14H,3-9H2,1-2H3 | |
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Yes |
General status |
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Insecticide | |
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Piperidine compound | |
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970 g kg⁻¹ | |
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None declared by manufacturer; Chemistry suggests sec-butyl chloroformate & sec-butyl carbonic anhydride | |
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Synthetic | |
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Topically applied, repellent. Odorant receptor. It has been proposed that icaridin may bind to odorant binding protein 1 (AgamOBP1). | |
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- | |
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119515-38-7 | |
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423-210-8 | |
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740 | |
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070705 | |
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125098 | |
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No data found | |
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- | |
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None allocated | |
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No | |
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- | |
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229.32 | |
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- | |
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(RS)-sec-butyl (RS)-2-(2-hydroxyethyl)piperidine-1-carboxylate | |
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1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate | |
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Colourless, odourless liquid |
Formulations |
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8200 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
High | ||||||||
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Miscible | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Propanol4 = Verified data |
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Miscible | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ethanol4 = Verified data |
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-170 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Freezing point3 = Unverified data of known source |
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296 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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375 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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1.70 X 1002 | Calculated | - | |||||||
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2.23 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Low | ||||||||
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1.04 | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
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Not applicable | Q4 Q = Miscellaneous data from online sources 4 = Verified data |
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No dissociation | |||||||||||
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0.034 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Low volatility | ||||||||
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Degradation |
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Stable | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Stable | |||||||
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Stable under normal environmental conditions | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | V1 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 1 = Estimated data with little or no verification |
Moderately mobile | |||||||
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389 | ||||||||||
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Estimated | ||||||||||
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Fate indices |
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1.8 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Whole fish4 = Verified data |
Low potential | |||||||||||||||||||||||||
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ND | - |
Known metabolites |
None
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Terrestrial ecotoxicology |
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2236 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat3 = Unverified data of known source |
Low | ||||||||
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100 | Q4 Q = Miscellaneous data from online sources Rat4 = Verified data |
Moderate | |||||||
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> 5000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Colinus virginianus4 = Verified data |
Low | ||||||||
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Aquatic ecotoxicology |
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173 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss4 = Verified data |
Low | ||||||||
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50.1 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss4 = Verified data |
Low | ||||||||
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100 | Q2 Q = Miscellaneous data from online sources Daphnia magna2 = Unverified data of unknown source |
Moderate | ||||||||
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103 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
Low | ||||||||
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71.5 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Scenedesmus subspicatus4 = Verified data |
Low | ||||||||
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54.8 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Scenedesmus subspicatus4 = Verified data |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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2236 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat3 = Unverified data of known source |
Low | ||||||||
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5000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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> 4.36 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Occupational exposure may occur through inhalation and dermal contact | ||||||||||
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The main route of excretion is urinary | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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US EPA - not likely to be a carcinogen |
Handling issues |
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Not explosive or oxidising | |||
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Health: H319 | |||
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III (Slightly hazardous) | |||
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|
icaridin | ||
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icaridin | ||
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Icaridin | ||
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icaridin | ||
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icaridin | ||
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icaridin | ||
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ikarydyna | ||
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icaridin | ||
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Record last updated: | 21/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |