Altrenogest (Ref: RU-2267) |
![]() Last updated: 15/09/2025 |
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(Also known as: ally trenbolone; RH-2267; A-35957; A-41300) |
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Altrenogest is a progestin used to control the reproductive cycle of various female animals, more specifically for the suppression or synchronisation of estrus | |
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Reproduction management | |
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Horses; Pigs |
Approval status |
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Approved - usually supplied as a prescription only medicine to be authorised by a veterinarian (POM-V) | |
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Approved |
Chemical structure |
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Altrenogest exhibits stereoisomerism, specifically configurational isomerism, due to the presence of multiple chiral centres in its steroid backbone. In addition, altrenogest is sensitive to photoisomerisation, meaning it can undergo structural changes when exposed to light. This process can lead to the formation of isomeric photoproducts. | |
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C₂₁H₂₆O₂ | |
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C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(CC=C)O | |
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VWAUPFMBXBWEQY-ANULTFPQSA-N | |
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InChI=1S/C21H26O2/c1-3-10-21(23)12-9-19-18-6-4-14-13-15(22)5-7-16(14)17(18)8-11-20(19,21)2/h3,8,11,13,18-19,23H,1,4-7,9-10,12H2,2H3/t18-,19+,20+,21+/m1/s1 | |
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Yes |
General status |
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Progestin, Medicinal drug | |
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19-nortestosterone drug | |
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Synthetic | |
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Progesterone receptor | |
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[Progesterone receptor, gonist] | |
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850-52-2 | |
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21-703-1 | |
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10041070 | |
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Sex hormones and modulators of the genital system; progestagens | |
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QG03DX90 | |
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No | |
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Allowed substance (Table 1: Porcine, Equidae) | |
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310.44 | |
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(8S,13S,14S,17R)-17-hydroxy-13-methyl-17-prop-2-enyl-1,2,6,7,8,14,15,16-octahydrocyclopental(α)phenanthren-3-one | |
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17α-allyestra-4,9-11-trien-17β-ol-3-one | |
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White to pale yellow coloured solid when pure. Products may be liquid. |
Commercial |
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Current | |||
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Early 1980's, first products launced | |||
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Usually administered orally | |||
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The commercial production of altrenogest involves a multi-step organic synthesis starting from 19-nortestosterone derivatives. The process typically includes alkylation at the 17alpha-position with an allyl group, followed by selective trienone formation across the steroid nucleus to yield the characteristic 4,9,11-triene structure. These steps require precise control of reaction conditions to maintain the correct stereochemistry at multiple chiral centres, which is essential for its potent activity at progesterone receptors. Once synthesised, the crude product undergoes purification via crystallisation or chromatography. | |||
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Published GHG data is not available for most pharmaceuticals. However, according to industry, global averages suggest producing 1 kg of a typical active pharmaceutical ingredient can range from 10 to 100 kg CO₂e for small molecule drugs and potentially up to 1000 kg CO₂e for complex biologicals such as vaccines, depending on the drug type, its formulation, complexity of synthesis, solvent recovery, and energy sources used. |
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62000 | E3 E = Manufacturers safety data sheets DMSO3 = Unverified data of known source |
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2000 | E3 E = Manufacturers safety data sheets Ethanol3 = Unverified data of known source |
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120 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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260 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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1.086 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Main environmental release is via the slurry and manure from treated livestock |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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> 2000 | E3 E = Manufacturers safety data sheets Rat as product3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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> 2000 | E3 E = Manufacturers safety data sheets Rat as product3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LD₅₀ = 176 mg kg⁻¹ bw | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Extensively metabolised in the liver and eliminated via bile, faeces and urine | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Health issues |
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May damage key organs if exposure is extensive IARC Group 2A carcinogen - progestins are prossible carcinogens Possible CNS and gastrointestinal tract toxicant |
Handling issues |
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May form thick soot and smoke if heated to decomposition | |||
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Health: H301, H313, H360fd, H373 Environment: H410 |
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Store at or below 25 DegC in the dark. Stable under ambient conditions. |
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altrenogest | ||
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Record last updated: | 15/09/2025 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |