Methoxychlor (Ref: OMS 466) |
Last updated: 26/08/2024 |
(Also known as: methoxychlore; dimethoxy-DT; dianisyl trichloroethane; ENT 1716; DMDT) |
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In veterinary practices, methoxychlor was once used as an ectoparasiticide | |
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Current | |
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circa 1948, introduced | |
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Use for general insect control | |
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Cats; Dogs; Cattle, Horses |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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A prochiral molecule | |
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C₁₆H₁₅Cl₃O₂ | |
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COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)C(Cl)(Cl)Cl | |
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- | |
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IAKOZHOLGAGEJT-UHFFFAOYSA-N | |
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InChI=1S/C16H15Cl3O2/c1-20-13-7-3-11(4-8-13)15(16(17,18)19)12-5-9-14(21-2)10-6-12/h3-10,15H,1-2H3 | |
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Yes |
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Common Name | Relationship | Link |
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methoxychlor | - |
General status |
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Insecticide | |
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Organochloride insecticide | |
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- | |
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- | |
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Synthetic | |
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Contact and stomach action. Central nervous stimulant, producing hyperactivity, convulsions and death. Sodium channel modulator. | |
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[Progesterone synthesis, Inhibitor] | |
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72-43-5 | |
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200-779-9 | |
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14 | |
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034001 | |
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4115 | |
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No data found | |
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- | |
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None allocated | |
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No | |
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- | |
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345.65 | |
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- | |
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1,1,1-trichloro-2,2-bis(4-methoxyphenyl)ethane | |
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1,1'-(2,2,2-trichloroethylidene)bis(4-methoxybenzene) | |
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POP candidate; OSPAR pfa | |
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- | |
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Colourless crystalline solid |
Formulations |
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0.1 | G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data |
Low | ||||||||
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440000 | L3 L = Pesticide manuals and hard copy reference books / other sources Xylene3 = Unverified data of known source |
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50000 | L3 L = Pesticide manuals and hard copy reference books / other sources Methanol3 = Unverified data of known source |
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700000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Trichloroethane3 = Unverified data of known source |
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1333000 | V2 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Dichloromethane2 = Unverified data of unknown source |
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87 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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6.76 X 1005 | Calculated | - | |||||||
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5.83 | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
High | ||||||||
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Soluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Regulatory data - observed in metabolism and farm animal feeding studies | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.41 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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0.08 | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
Low volatility | ||||||||
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2.00 X 10-02 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Non-volatile | ||||||||
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- |
Degradation |
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120 | G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data |
Persistent | |||||||
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120 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Persistent | ||||||||
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Best available data | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | G3 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 3 = Unverified data of known source |
Non-mobile | |||||||
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80000 | ||||||||||
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Best available data | ||||||||||
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Fate indices |
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-1.88 | Calculated | Low leachability | ||||||||||||||||||||||||||
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1622 | E3 E = Manufacturers safety data sheets (Other literature values Log BCF range 2.8-4.1 (R3))3 = Unverified data of known source |
Threshold for concern | |||||||||||||||||||||||||
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Not available | - |
Known soil metabolites |
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Known groundwater metabolites |
None
Other known metabolites |
None
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Terrestrial ecotoxicology |
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> 6000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
Low | ||||||||
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- | L2 L = Pesticide manuals and hard copy reference books / other sources Rat 2 yr2 = Unverified data of unknown source |
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200 | - | |||||||||
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> 2000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Anas platyrhynchos4 = Verified data |
Low | ||||||||
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> 23.6 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Apis mellifera4 = Verified data |
Moderate | |||||||
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5.0 | K3 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) Apis mellifera3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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0.052 | L3 L = Pesticide manuals and hard copy reference books / other sources Oncorhynchus mykiss3 = Unverified data of known source |
High | ||||||||
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> 0.59 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio Embryo3 = Unverified data of known source |
Moderate | ||||||||
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0.00078 | L3 L = Pesticide manuals and hard copy reference books / other sources Daphnia magna3 = Unverified data of known source |
High | ||||||||
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0.001 | P3 P = Other non-EU, UK or US Governments and Regulators Daphnia magna3 = Unverified data of known source |
High | ||||||||
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0.014 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ceriodaphnia dubia4 = Verified data |
High | ||||||||
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36.7 | R3 R = Peer reviewed scientific publications Chironomus dilutus 10 day LC₅₀3 = Unverified data of known source |
Moderate | ||||||||
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0.6 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Scenedesmus quadricauda4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 6000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
Low | ||||||||
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2000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rabbit3 = Unverified data of known source |
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0.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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List I; List II | - | - | ||||||||
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Metabolised and mainly eliminated through the faeces | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Endocrine issues - strong estrogenic effect Potential kidney & liver toxicant IARC Group 3 carcinogen - not classifiable; CLP data - suspected carcingen May damage vital organs |
Handling issues |
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Highly flammable and easily ignited by heat, sparks and flames IMDG Transport Hazard Class 6.1 |
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Health: H302, H312, H332, H351, H371 Environment: H400 |
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U (Unlikely to present an acute hazard) | |||
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UN2761 | |||
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Packaging Group III (minor danger) | |||
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methoxychlor | ||
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methoxychlore | ||
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Methoxychlor | ||
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methoxychlor | ||
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metossicloro | ||
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metoxiclor | ||
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metoksychlor | ||
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Record last updated: | 26/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |