Azamethiphos (Ref: GCA 18809) |
Last updated: 24/10/2024 |
(Also known as: OMS 1825) |
SUMMARY |
Azamethiphos is an organophosphate used as an insecticide and as an antiparasitic agent for veterinary use. It is highly soluble in water, volatile and not expected to leach to groundwater. Not a great deal is known about its environmental persistence. It is moderately toxic to mammals and not expected to bioaccumulate. It is a mutagen, neurotoxicant and an acetyl cholinesterase inhibitor. Azamethiphos is highly toxic to birds and aquatic invertebrates and moderately toxic to fish. |
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An organophoshorus insecticide used for parasitic control | |
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Current | |
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1970, introduced | |
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Used in fish farming to control external parasites on Atlantic Salmon and for parasite control on other animals | |
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Salmon; Dogs; cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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None | |
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C₉H₁₀ClN₂O₅PS | |
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COP(=O)(OC)SCN1C2=NC=C(C=C2OC1=O)Cl | |
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No data | |
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VNKBTWQZTQIWDV-UHFFFAOYSA-N | |
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InChI=1S/C9H10ClN2O5PS/c1-15-18(14,16-2)19-5-12-8-7(17-9(12)13)3-6(10)4-11-8/h3-4H,5H2,1-2H3 | |
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Yes |
General status |
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Antiparasitic, Veterinary hygiene | |
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Organophosphate insecticide; Organothiophosphate insecticide | |
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>95% | |
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- | |
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Synthetic | |
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Contact and stomach action, rapid knockdown. Acetylcholinesterase (AChE) inhibitor. | |
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[Cholinesterase, Inhibitor] | |
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35575-96-3 | |
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252-626-0 | |
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None allocated | |
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129101 | |
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71482 | |
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Antiparasitic products, insecticides & repellents: Ecoparasiticides, insecticides & repellents | |
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QP53AF17 | |
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No | |
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Allowed substance (Table 1: Salmonidae) | |
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324.68 | |
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S-[(6-chloro-2-oxo-1,3-oxazolo[4,5-b]pyridin-3(2H)-yl)methyl] O,O-dimethyl phosphorothioate | |
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S-6-chloro-2,3-dihydro-2-oxo-1,3-oxazolo[4,5-b]pyridin-3-ylmethyl O,O-dimethyl phosphorothioate | |
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S-[(6-chloro-2-oxooxazolo[4,5-b]pyridin-3(2H)-yl)methyl] O,O-dimethyl phosphorothioate | |
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PAN Bad Actor Chemical | |
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UK non-statutory standard for protection of freshwater and saltwater aquatic life 0.02 µg l⁻¹ as annual average, 0.05 as max acceptable conc. | |
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Colourless to grey cystalline solid |
Formulations |
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Salmosan Powder for Suspension for Fish Treatment | Benchmark Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Azasure powder suspension for fish treatment | Ground Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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For treatment of fish azamethiphos is formulated as a water soluble powder for administration using a process known as the 'Bath Technique'. |
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1100 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
High | ||||||||
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610000 | L3 L = Pesticide manuals and hard copy reference books / other sources Dichloromethane3 = Unverified data of known source |
- | ||||||||
130000 | L3 L = Pesticide manuals and hard copy reference books / other sources Benzene3 = Unverified data of known source |
- | |||||||||
100000 | L3 L = Pesticide manuals and hard copy reference books / other sources Methanol3 = Unverified data of known source |
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5800 | L3 L = Pesticide manuals and hard copy reference books / other sources n-Octanol3 = Unverified data of known source |
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89 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Decomposes before boiling | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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150 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.12 X 1001 | Calculated | - | |||||||
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1.05 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Low | ||||||||
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- | - | - | |||||||
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- | - | - | ||||||||
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1.6 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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- | - | - | ||||||||
- | |||||||||||
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0.0049 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Low volatility | ||||||||
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1.45 X 10-06 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Non-volatile | ||||||||
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- | - | - | ||||||||
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- | - | - | ||||||||
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- |
Degradation |
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0.25 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Non-persistent | |||||||
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- | - | - | ||||||||
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Best available data, Industry data DT₅₀ in loamy sand circa 6 hours (E3) | ||||||||||
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- | - | - | ||||||||
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- | - | - | |||||||
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- | ||||||||||
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11 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Non-persistent | |||||||
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pH sensitive ranging from 33 days at pH 5 to 4.3 hrs at pH 9 | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | S1 S = Expert judgement 1 = Estimated data with little or no verification |
Mobile | |||||||
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25 | ||||||||||
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Estimated | ||||||||||
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- | ||||||||||
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- | ||||||||||
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- | ||||||||||
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- |
Fate indices |
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-1.57 | Calculated | Low leachability | ||||||||||||||||||||||||||
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1.56 | Q2 Q = Miscellaneous data from online sources Estimated2 = Unverified data of unknown source |
Low potential | |||||||||||||||||||||||||
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Not available | - |
Known metabolites |
None
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Terrestrial ecotoxicology |
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1180 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
Moderate | ||||||||
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2 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
High | |||||||
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20 | - | |||||||||
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- | - | - | ||||||||
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> 30.2 | L3 L = Pesticide manuals and hard copy reference books / other sources Colinus virginianus3 = Unverified data of known source |
High | ||||||||
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10.0 | R3 R = Peer reviewed scientific publications Apis mellifera3 = Unverified data of known source |
Moderate | |||||||
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0.1 | R3 R = Peer reviewed scientific publications Apis mellifera3 = Unverified data of known source |
High | ||||||||
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Aquatic ecotoxicology |
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> 0.115 | L3 L = Pesticide manuals and hard copy reference books / other sources Oncorhynchus mykiss3 = Unverified data of known source |
Moderate | ||||||||
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- | - | - | ||||||||
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7.76 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio4 = Verified data |
Moderate | ||||||||
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0.00067 | L3 L = Pesticide manuals and hard copy reference books / other sources Daphnia magna3 = Unverified data of known source |
High | ||||||||
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General |
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High (class III) | - | - | ||||||||
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1180 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
Moderate | ||||||||
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2150 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
- | ||||||||
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> 0.56 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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- | - | - | ||||||||
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0.025 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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List I; List II | - | - | ||||||||
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In rats azamethiphos is excreted via faeces, urine & in expelled air. In fish adsorption after topical application is slow and low. Excretion is rapid in all species. | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
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Health issues |
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Mutagenic potential |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Health: H302, H317, H332 Environment: H400, H410 |
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II (Moderately hazardous) | |||
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UN2783 | |||
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azamethiphos | ||
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azametiphos | ||
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Azamethiphos | ||
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azamethiphos | ||
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azametifos | ||
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azametifos | ||
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- | ||
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azametifos | ||
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azametifos | ||
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- | ||
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azamethifos | ||
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- |
Record last updated: | 24/10/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |