Pyraclofos (Ref: OMS 3040) |
Last updated: 05/02/2024 |
(Also known as: TIA 230) |
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An obsolete organophosphate insecticide used for external and internal parasite control | |
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- | |
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1989, registered Japan | |
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Substance used for eradicating parasites such as helminths, nematodes, ticks and others | |
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Cattle; Horses; Sheep; Pigs; Poultry; Cats; Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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A molecule with one chiral centre resulting in a pair of enantiomers: S-(+)- and R-(−)-pyraclofos | |
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C₁₄H₁₈ClN₂O₃PS | |
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CCCSP(=O)(OCC)OC1=CN(N=C1)C2=CC=C(C=C2)Cl | |
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No data | |
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QHGVXILFMXYDRS-UHFFFAOYSA-N | |
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InChI=1S/C14H18ClN2O3PS/c1-3-9-22-21(18,19-4-2)20-14-10-16-17(11-14)13-7-5-12(15)6-8-13/h5-8,10-11H,3-4,9H2,1-2H3 | |
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Yes |
General status |
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Antiparasitic, Insecticide | |
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Organophosphate insecticide; Orgnothiophosphate insecticide; Phenylpyrazole insecticide | |
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- | |
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Synthetic | |
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Respiratory, contact and stomach action. Acetylcholinesterase inhibitor. | |
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[Cholinesterase, Inhibitor] | |
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89784-60-1 | |
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77458-01-6 | |
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618-301-6 | |
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None allocated | |
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- | |
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93460 | |
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No data found | |
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- | |
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None allocated | |
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No | |
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- | |
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360.8 | |
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- | |
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(RS)-[O-1-(4-chlorophenyl)pyrazol-4-yl O-ethyl S-propyl phosphorothioate] | |
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O-[1-(4-chlorophenyl)-1H-pyrazol-4-yl] O-ethyl S-propyl phosphorothioate | |
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Evidence of use in third world countries; PAN listed Highly Hazardous Chemical | |
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- | |
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Pale yellow oil |
Formulations |
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Coopers Colleague Broad Spectrum Sheep & Lamb Drench | Schering-Plough Animal Health | Not licensed | Not licensed | ||||||
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33 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Low | ||||||||
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Miscible | L3 L = Pesticide manuals and hard copy reference books / other sources Acetone3 = Unverified data of known source |
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Miscible | L3 L = Pesticide manuals and hard copy reference books / other sources Ethanol3 = Unverified data of known source |
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Miscible | L3 L = Pesticide manuals and hard copy reference books / other sources Methanol3 = Unverified data of known source |
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Not applicable | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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454 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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5.89 X 1003 | Calculated | - | |||||||
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3.77 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
High | ||||||||
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1.271 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.60 X 10-03 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Low volatility | ||||||||
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1.75 X 10-05 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Non-volatile | ||||||||
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Degradation |
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39 | K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data |
Moderately persistent | |||||||
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50 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Moderately persistent | ||||||||
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Best available data | ||||||||||
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29 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Non-persistent | |||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
Slightly mobile | |||||||
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2095 | ||||||||||
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Estimated | ||||||||||
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Fate indices |
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1.15 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Known soil and groundwater metabolites |
None
Other known metabolites |
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1-(4-chlorophenyl)pyrazol-4-yl-6-O-malonyl-beta-D-glcopyranoside | - | Plant | 0.51 | ||||
1-(4-chlorophenyl)pyrazo-4-yl sulfate | - | Rat (Urine) | 0.7 | ||||
desethylpyraclofos | - | Rat (Urine, Faecal) | - | ||||
1-(4-chlorophenyl)pyrazol-4-yl-beta-D-glcopyranoside | - | Plant | - | ||||
des-S-propylpyraclofos | - | Rat (Urine, Faecal) | - | ||||
O-ethyl-S-propyl-phosphorothioate | - | Rat (Urine) | - | ||||
monoethylphosphate | - | Rat (Urine) | - |
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Terrestrial ecotoxicology |
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237 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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0.1 | L2 L = Pesticide manuals and hard copy reference books / other sources Rat 2 yr2 = Unverified data of unknown source |
High | |||||||
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164 | L3 L = Pesticide manuals and hard copy reference books / other sources Colinus virginianus3 = Unverified data of known source |
Moderate | ||||||||
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0.953 | L3 L = Pesticide manuals and hard copy reference books / other sources Apis mellifera3 = Unverified data of known source |
High | |||||||
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Aquatic ecotoxicology |
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0.028 | L3 L = Pesticide manuals and hard copy reference books / other sources Cyprinidae spp.3 = Unverified data of known source |
High | ||||||||
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General |
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High (class III) | - | - | ||||||||
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237 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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2000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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1.46 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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List I; List II | - | - | ||||||||
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Rapidly absorbed, metabolised and excreted in the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Harmful if swallowed |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Health: H301 | |||
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II (Moderately hazardous) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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pyraclofos | ||
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pyraclofos | ||
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Pyraclofos | ||
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pyraclofos | ||
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piraclofos | ||
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piraclofos | ||
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pyraklofos | ||
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Record last updated: | 05/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |