Ascomycin (Ref: SPRI-2098) |
![]() Last updated: 23/08/2025 |
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(Also known as: immunomycin; FR-900520; FK520) |
SUMMARY |
This is a micro-organism pesticide for which little data is currently available. The substance is not commercially available and will be subject to regulatory risk assessment before this can happen. |
Hazard alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate | Ecotoxicity | Human health |
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  |   | ![]() Significant data are missing |
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An experimental fungicide that is highly effective for the control of botrytis cinerea on various crops | |
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Grey mold (botrytis cinerea) | |
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Ttomato: Cucumber; Strawberry; Aubergine; Summer squash | |
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GB regulatory status |
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Not approved | ||
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Not applicable | ||
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No UK approval for use as a plant protection agent |
EC Regulation 1107/2009 (repealing 91/414) |
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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Chemical structure |
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Ascomycin exhibits structural and stereoisomerism due to its highly intricate molecular architecture. Its macrocyclic ring contains multiple chiral centres, leading to numerous stereoisomers (including enantiomers and diastereomers. Additionally, the molecule’s tricarbonyl binding domain is highly reactive and can form various equilibrium isomers, such as furano-ascomycins, through intramolecular rearrangements or tautomeric shifts. | |
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C₄₃H₆₉NO₁₂ | |
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CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C | |
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CC[C@@H]1/C=C(\C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC)C)/C | |
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ZDQSOHOQTUFQEM-PKUCKEGBSA-N | |
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InChI=1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3 | |
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Yes |
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Common Name | Relationship | Link |
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monohydrate | Variant | ![]() |
General status |
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Fungicide | |
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Micro-organism derived substance | |
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Natural | |
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Suppresses fungal growth | |
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Ascomycin is produced by the fermentation of Streptomyces hygroscopicus | |
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Crop protection | |
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botrytis cinerea | |
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Tomato: Cucumber; Strawberry; Aubergine; Summer squash | |
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11011-38-4 | |
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104987-12-4 | |
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5282071 | |
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792.01 | |
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(3S,4R,5S,8R,9Z,12S,14S,15R,16S,18R,19R,26αS)-8-ethyl-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26α-heptadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotriclosine-1,7,20,21(23H)-tetrone | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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Off-white solid |
Commercial |
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Novel | |||
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1960s, first isolated; 2004, introduced | |||
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Ascomycin is produced primarily through microbial fermentation using Streptomyces hygroscopicus subsp. ascomyceticus, as its complex macrocyclic structure makes chemical synthesis impractical. The biosynthesis involves polyketide pathways, and production is typically carried out in optimised fermentation media. Recent advances have focused on enhancing yield through genetic engineering, such as overexpressing key biosynthetic genes and manipulating metabolic pathways. | |||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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1.6 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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1.6 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Health issues |
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No information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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ascomycin | ||
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Record last updated: | 23/08/2025 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |