Romidepsin (Ref: FK228) |

Last updated: 25/08/2025
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(Also known as: depsipeptide) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate |
Ecotoxicity |
Human health |
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A natural proherbicide which also demonstrates some insecticidal activity. It is produced by several microorganisms including Chromobacterium violaceum and Burkholderia rinojensis |
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Pigweed (Amaranthus palmeri L.); Charlock (Sinapis arvensis L).; Blowfly larvae |
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Not approved |
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Not applicable |
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No UK approval for use as a plant protection agent |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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Romidepsin exhibits stereoisomerism, specifically geometric (E/Z) isomerism and optical isomerism, due to its complex macrocyclic structure and multiple chiral centres. |
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C₂₄H₃₆N₄O₆S₂ |
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CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C |
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C/C=C\1/C(=O)N[C@H](C(=O)O[C@H]\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C |
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OHRURASPPZQGQM-GCCNXGTGSA-N |
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InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1 |
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Yes |
Cambridge Crystallographic Data Centre diagrams |
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Common Name |
Relationship |
Link |
romidepsin |
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Herbicide; Insecticide |
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Peptide herbicide; Peptide insecticide; Micro-organism derived substance |
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Natural |
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Plant and insect histone deacetylases inhibitor |
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It is produced by several microorganisms including Chromobacterium violaceum and Burkholderia rinojensis strain A396 |
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Crop protection; General pest management |
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Carelessweed (Amaranthus palmeri L.); Charlock (Sinapsis arvensis L.); Blowfly larvae |
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128517-07-7 |
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686-179-1 |
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5352062 |
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540.7 |
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(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone |
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Not known |
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Not known |
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Not known |
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Not applicable |
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White to off-white coloured solid |
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Current |
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Romidepsin is produced through a fermentation-based process using the soil bacterium Chromobacterium violaceum, which naturally synthesises this compound. Under carefully controlled conditions, cultures of the bacterium are grown and induced to produce romidepsin. After fermentation, the compound is extracted and purified using chromatographic techniques and recrystallisation to ensure quality. |
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20000 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source DMSO |
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10000 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Ethanol |
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220 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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524 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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8.91 X 1000 |
Calculated |
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0.95 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Low |
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1.2 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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HUMAN HEALTH AND PROTECTION |
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Intraperitoneal LD₅₀ = 6.4 mg kg⁻¹ |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Mouse |
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Intravenous LD₅₀ = 10.0 mg kg⁻¹ |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Mouse |
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Carcinogen |
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Endocrine disruptor |
XNo, known not to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E1 E = Unspecified genotoxicity type (miscellaneous data source) 1 = Positive |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
XNo, known not to cause a problem |
✓Yes, known to cause a problem |
Eye irritant |
Phototoxicant |
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XNo, known not to cause a problem |
No data found |
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Possible anti-cancer agent |
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IMDG Transport Hazard Class 6.1 |
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Health: H301, H317, H341 Environment: H400, H410 |
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Not listed (Not listed) |
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UN2811 |
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Packaging group III (minor danger) |
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Light sensitive, store in dark. |
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romidepsin |
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Record last updated: |
25/08/2025 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |