Beta-sitosterol |

Last updated: 25/08/2025
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(Also known as: beta-sitosterin; stigmast-5-en-3beta-ol; 22,23-dihydrostigmasterol; quebrachol; βSito) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate |
Ecotoxicity |
Human health |
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A novel Chinese phytosterol plant metabolite with some anti-fungal activity |
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Not approved |
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Not applicable |
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No UK approval for use as a plant protection agent |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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Beta-sitosterol is an isomer of other phytosterols, such as campesterol and stigmasterol |
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C₂₉H₅₀O |
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CC[C@H](CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C |
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KZJWDPNRJALLNS-VJSFXXLFSA-N |
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InChI=1S/C29H50O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h10,19-21,23-27,30H,7-9,11-18H2,1-6H3/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1 |
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Yes |
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Fungicide; Virucide |
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Phytosterol fungicide; Plant-derived substance |
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>98% |
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Natural |
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A sterol methyltransferase inhibitor |
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A naturally occurring phytosteroid found in elevated concentrations in vegetable oils, nuts, seeds, cereals and fruits |
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Crop protection |
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83-46-5 |
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201-480-6 |
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222284 |
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414.74 |
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(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
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(1R,3aS,3bS,7S,9aR,9bS,11aR)-1-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-9a,11a-dimethyl-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-ol |
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(3β)-stigmast-5-en-3-ol |
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Not applicable |
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Not applicable |
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Not applicable |
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Not applicable |
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White waxy powder |
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Novel |
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2024, launch |
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- Shaanxi Sunger Road Bio-Science Co.
- Ltd
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Beta-sitosterol is commercially produced through extraction from plant-based sources rich in phytosterols, such as soybean oil, tall oil (a byproduct of wood pulping), and other vegetable oils. The process typically begins with refining these oils to isolate sterol-rich fractions, followed by purification using advanced techniques like supercritical fluid extraction, which employs carbon dioxide under high pressure to selectively extract beta-sitosterol. Other methods include ultrasound-assisted, enzyme-assisted, and microwave-assisted extraction, each designed to maximise yield and preserve compound integrity. Beta-sitosterol can also be isolated from the herbage of Anemone cathayensis Kitag. |
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136 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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502 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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0.98 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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HUMAN HEALTH AND PROTECTION |
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Carcinogen |
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Endocrine disruptor |
No data found |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
No data found |
No data found |
Eye irritant |
Phototoxicant |
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No data found |
No data found |
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No information available |
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No information available |
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Store at -20°C. Shelf-life ~ 1 year |
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beta-sitosterol |
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β-sitosterol |
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Record last updated: |
25/08/2025 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |