Agrobody ASFBIOF01-02

Agrobody ASFBIOF01-02	Last updated: 29/04/2026
(Also known as: Agrobody, anti-fungal VHH; ASFBIOF01-02 Polypeptide)

Hazard alerts

The following Pesticide Hazard Tricolour (PHT) alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. The alerts for Highly Hazardous Pesticides (HHPs) are based on applying the FAO/WHO (Type 1) and the PAN (Type II) criteria to PPDB data. Further details on the HHP indicators are given in the tables below. Neither the PHT nor the HHP hazard alerts take account of usage patterns or exposure, thus they do not represent risk.

PHT: Environmental fate	PHT: Ecotoxicity	PHT: Human health	Highly Hazardous Pesticide
	Ecotoxicity Moderate alert: Birds acute ecotoxicity: Moderate; Fish acute ecotoxicity: Moderate; Bees acute oral ecotoxicity: Moderate	Human health Low alert

GENERAL INFORMATION

Description

A novel protein-based, broad-spectrum biofungicide, used pre-and post-harvest, developed using the innovative Agrobody Foundry Platform

Example pests/issues controlled

Grey mould (Botrytis cinerea); Powdery mildew

Example applications

Fruit including citrus, pome, berries and stone fruit; Vegetables; Grapes; Ornamentals; Hemp; Tobacco

Efficacy & activity

Field trials demonstrate moderate fungal control compared with traditional low risk fungicides. Works best at low to moderate pest pressure. In specific grape varieties when grown in the Mediterranean zone and strawberry grown under protected conditions some phytotoxic symptoms (necrosis) were observed.

Appearance and life cycle

Taxonomic classification

GB regulatory status

GB COPR regulatory status

Not approved

Date COPR inclusion expires

Not applicable

GB LERAP status

No UK approval for use as a crop protection agent

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Pending

Dossier rapporteur/co-rapporteur

Netherlands

Date EC 1107/2009 inclusion expires

Not applicable

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece

ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg

LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway

Additional information

Also used in

Brazil; USA

Chemical structure

Isomerism

Not applicable

Chemical formula

C₅₇₇H₉₀₅N₁₆₉O₁₇₇S₄

Canonical SMILES

Isomeric SMILES

International Chemical Identifier key (InChIKey)

International Chemical Identifier (InChI)

2D structure diagram/image available?

General status

Biopesticide type

Fungicide

Substance groups

Peptide fungicide; Animal-derived fungicide

Minimum active substance purity

1.5 – 2.3 % w/w (technical grade)

Known relevant impurities

EFSA 2026: no relevant impurities

Substance origin

Natural

Mode of action

Substance binds to fungal membranes, disrupting its integrity which causes cell rupture and fungal death

Substance source

Proteins inspired by the top fragment of an antibody generated by Camelidae. The substance is an antigen binding fragment of an antibody that was originally identified in llamas immunised with a lipid extract from the phytopathogenic fungus Fusarium oxysporum.

Uses

Crop protection

Farming system suitability

Suitable for all farming systems where approved for use in that country

CAS RN

EC number

CIPAC number

US EPA chemical code

PubChem CID

Molecular mass (Da)

13200

Chemical name

Agrobody antifungal VHH (ASFB10F01-02)

PIN (Preferred Identification Name)

IUPAC name

CAS name

Global Governance status: Listed (✓) under

UK Poisons List Order 1972	Rotterdam Convention	Montreal Protocol
XNo The Poisons List Order 1972	XNo Rotterdam Convention	XNo Montreal Protocol
Stockholm Convention	OSPAR	EU Water Framework Directive
XNo Stockholm Convention	XNo OSPAR	XNo EU Water Framework Directive

Relevant Environmental Water Quality Standards

Forever chemical

Highly Hazardous Pesticide (HHP)

Type I

Type II

Other status information

Herbicide Resistance Class (HRAC MoA class)

Not applicable

Herbicide Resistance Class (WSSA MoA class)

Not applicable

Insecticide Resistance Class (IRAC MoA class)

Not applicable

Fungicide Resistance Class (FRAC MOA class)

F10 (under Group 51)

Examples of recorded resistance

Not applicable

Physical state

Formulated as a solid product

Commercial

Property

Value

Availability status

Novel

Introduction & key dates

2025, registered USA; 2026, approval sought EU

Example manufacturers & suppliers of products using this active now or historically

Biotalys NV Belgium

Example products using this active

Evoca

Formulation and application details

Supplied as a water-soluble granule formulation which can be applied via foliar spraying, dipping, drenching or mist/fogging

Commercial production

The biofungicide is manufactured through an industrial scale bioprocess and formulated to meet farmers' practice, ensuring consistent high performance and novel modes of action. The bioactive ingredients are produced by fermentation in simple microorganisms such as yeast followed by filtration steps, limiting the amount of energy and waste from the production.

Impact on climate of production and use

Fermentation-based production processes typically have a low fossil fuel input in formulation and active ingredient creation, and also have reduced downstream emissions due to biodegradability and minimal soil disruption, their life-cycle GHG emissions are expected to be low. Whilst hard and precise data is not available, broad estimates suggest that typically emissions are likely to be below 5 kg CO₂e/kg.

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C at pH 7 (mg l⁻¹)

1000000

High

Solubility - In organic solvents at 20 °C (mg l⁻¹)

10000

Acetone

10000

Methanol

10000

Ethyl acetate

10000

n-Heptane

Melting point (°C)

-5

Boiling point (°C)

Degradation point (°C)

None observed

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

Log P

Fat solubility of residues

Solubility

Data type

Density (g ml⁻¹)

Dissociation constant pKa) at 25 °C

Not applicable

No dissociation

Vapour pressure at 20 °C (mPa)

2.06 X 10⁰⁶

Highly volatile. If applied directly to plants or soil, drift is a concern & mitigation is advisable

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Max. between 210-215 nm.
No significant absorbance observed between 290-400 nm (and expected up to 700 nm)

Surface tension (mN m⁻¹)

38.72

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Biodegradable

Soil degradation (days) (aerobic)

DT₅₀ (typical)

DT₅₀ (lab at 20 °C)

DT₅₀ (field)

DT₉₀ (lab at 20 °C)

DT₉₀ (field)

DT₅₀ modelling endpoint

Note

Rapid environmental dispersal leaving no residues - proteins degrade into smaller peptides and further into amino acids,

Dissipation rate RL₅₀ (days) on plant matrix

Value

Note

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Note

Water-sediment DT₅₀ (days)

Water phase only DT₅₀ (days)

Sediment phase only DT₅₀ (days)

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

K_oc (mL g⁻¹)

Notes and range

Freundlich

K_f (mL g⁻¹)

K_foc (mL g⁻¹)

¹/_n

Notes and range

pH sensitivity

Known metabolites

None

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 5000

Rat

Low

Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Birds - Acute LD₅₀ (mg kg⁻¹)

> 394

Coturnix japonica

Moderate

Birds - Short term dietary LC₅₀ (mg kg⁻¹ bw d⁻¹)

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹ dw soil)

> 1000

Eisenia foetida

Low

Soil micro-organisms

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Non-target plants

Vegetative vigour ER₅₀ (g ha⁻¹)

> 900

10 plants tested

Seedling emergence ER₅₀ (g ha⁻¹)

> 900

10 plants tested

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 101

Apis mellifera

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 81.5

Apis mellifera

Moderate

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Notes

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 80.0

Bombus spp.

Moderate

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 99.4

Bombus spp.

Moderate

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps) as Mortality LR₅₀ g ha⁻¹, Std lab test

> 2100

Aphidius rhopalosiphi

Low

Beneficial insects (Predatory mites) as Mortality LR₅₀ g ha⁻¹, Std lab test

> 2100

Typhlodromus pyri

Low

Beneficial insects (Ground beetles)

Beneficial insects (Butterflies)

Contact

Notes

Oral

Notes

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

> 76.1

Unknown species

Moderate

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

> 63.3

Danio rerio

Moderate

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

> 100

Daphnia magna

Low

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l⁻¹)

Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l⁻¹)

Algae - Acute (growth rate, fresh; mg l⁻¹) (ErC₅₀ 72 hr)

63.4

Green algae

Low

Algae - Chronic (growth rate, fresh; mg l⁻¹) (LOEC 72 hr)

0.294

Green algae

Moderate

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

Regulatory Threshold Levels (RTLs)

Note: These RTLs have been calculated using the regulatory approach used in the European Union and based on ecotoxocity values in the PPDB.

Species group

RTL

Notes

Mammals

500

Worst case of acute and chronic mammals

Birds

39.4

Worst case of acute and chronic birds

Soil organisms

200

Worst case of acute and chronic earthworms

Terrestrial plants

180

Worst case of non-target plants vegetative vigour and seedling emergence

Pollinators

1.63

Worst case of contact and oral honeybees

Arthropods

1050

Worst case of parasitic wasps and predatory mites

Fish

0.761

Worst case of temperate acute and chronic fish

Aquatic invertebrates

Worst case of temperate acute and chronic aquatic invertebrates

Aquatic plants

0.0294

Worst case of free-floating plants, rooted plants, acute and chronic algae

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

Not applicable

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 5000

Rat

Low

Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

> 5000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 2.02

Rat 4 hr

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

None allocated

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

None allocated

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

None allocated

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

None allocated

Dermal penetration studies (%)

10-50%

default

Dangerous Substances Directive 76/464

Exposure Routes

Public

No significant risks identified or anticipated

Occupational

No significant risks identified or anticipated

Mammalian dose elimination route and rate

Health issues

Specific human health issues (hazard-based)

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

Respiratory tract irritant

Skin irritant

Skin sensitiser

Eye irritant

Phototoxicant

General human health issues

Exposure should not result in unreasonable adverse effects to humans

Handling issues

Property

Value and interpretation

General

Not explosive or oxidising
Not highly flammable; Not expected to auto-ignite

CLP classification 2013

Health: H317

WHO Classification

Not listed

UN Number

Waste disposal & packaging

Shelf-life, storage, stability and reactivity

TRANSLATIONS

Language

Name

English

Agrobody ASFBIOF01-02

French

German

Danish

Italian

Spanish

Greek

Polish

Swedish

Hungarian

Dutch

Norwegian

Record last updated:	29/04/2026
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242

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