Medetomidine |

Last updated: 24/10/2024
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(Not known by any other names) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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Used as an antifouling substance in marine paint and as a general anaesthetic as a sedative and analgesic drug for a variety of animals. |
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Barnacles; Tube worms; Fungi; Algae |
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Paint |
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- |
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Current |
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- |
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Not approved |
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Not applicable |
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No UK approval for use as a pesticide |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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Isomeric. The biologically active dextroisomer of medetomidine is known as dexmedetomide |
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C₁₃H₁₆N₂ |
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CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C |
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- |
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CUHVIMMYOGQXCV-UHFFFAOYSA-N |
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InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15) |
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Yes |
Cambridge Crystallographic Data Centre diagrams |
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Veterinary substance, Other substance |
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Biocide, Antifouling agent |
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Unclassified substance |
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>99% |
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- |
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Synthetic |
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A non-narcotic alpha2-adrenoreceptor agonist |
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86347-14-0 |
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811-718-6 |
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None allocated |
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- |
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69602 |
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No data found |
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200.28 |
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- |
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(RS)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole |
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- |
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- |
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- |
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Not applicable |
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Not applicable |
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Not applicable |
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Not applicable |
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- |
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White crystalline, odourless powder |
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19800 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
High |
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3300 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source p-Xylene |
- |
65000 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source Acetone |
- |
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116 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
- |
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382 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
- |
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- |
- |
- |
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191.3 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
- |
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7.94 X 1002 |
Calculated |
- |
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2.9 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Moderate |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
- |
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3.5 X 10-03 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Low volatility |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
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100 |
E2 E = Manufacturers safety data sheets 2 = Unverified data of unknown source |
Persistent |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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Literature: Slow degradation |
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- |
- |
- |
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- |
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- |
- |
- |
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- |
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- |
- |
- |
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- |
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- |
- |
- |
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- |
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110 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Slow |
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- |
- |
- |
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- |
- |
- |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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- |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Slightly mobile |
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2460 |
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Literature data range Koc 1215 to 3705 g/mL |
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- |
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- |
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- |
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1.22 |
Calculated |
Low leachability |
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2.77 X 10-02 |
Calculated |
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- |
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High |
Calculated |
- |
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Slightly mobile |
Calculated |
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- |
- |
- |
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- |
- |
- |
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- |
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None
Terrestrial ecotoxicology |
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> 31.25 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source Rat |
High |
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- |
- |
- |
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- |
- |
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- |
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- |
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- |
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30.0 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source Danio rerio |
Moderate |
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4.5 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Moderate |
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- |
- |
- |
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- |
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- |
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0.005 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source Americamysis bahia as 28 day NOEC |
High |
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- |
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- |
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0.34 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source Scenedesmus subspicatus |
Moderate |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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> 31.25 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source Rat |
High |
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2000 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source Rat |
- |
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0.14 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source Rat 4 hr |
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EU MRL pesticide database |
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Metabolised and excreted via the kidneys in the urine. |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Carcinogen |
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Endocrine disruptor |
XNo, known not to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
✓Yes, known to cause a problem |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
✓Yes, known to cause a problem |
?Possibly, status not identified |
No data found |
Eye irritant |
Phototoxicant |
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?Possibly, status not identified |
No data found |
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Possible lungs, liver and kidney toxicant May cause hypersensitivity reactions Harmful if swallowed Has a strong sedative effect |
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Emits a variety of toxic fumes on combustion Corrosive Not explosive or oxidising |
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Health: H300, H310 Environment: H400, H410 |
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Not listed (Not listed) |
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Not regulated |
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medetomidine |
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medetomidina |
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Record last updated: |
24/10/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |