S-methoprene (Ref: SAN 810) |
Last updated: 25/08/2024 |
(Also known as: d-methoprene; ZR 2458; methoprene) |
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Juvenile hormone mimic insecticide used for external parasite control | |
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Current | |
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1975, introduced USA | |
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Topically applied to control fleas and ticks | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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S-methoprene is the trans-form of the chiral methoprene and is more biologically active that the cis-form. | |
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C₁₉H₃₄O₃ | |
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CC(C)OC(=O)C=C(C)C=CCC(C)CCCC(C)(C)OC | |
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CC(C)OC(=O)/C=C(\C)/C=C/CC(C)CCCC(C)(C)OC | |
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NFGXHKASABOEEW-LDRANXPESA-N | |
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InChI=1S/C19H34O3/c1-15(2)22-18(20)14-17(4)11-8-10-16(3)12-9-13-19(5,6)21-7/h8,11,14-16H,9-10,12-13H2,1-7H3/b11-8+,17-14+ | |
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Yes |
General status |
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Ecoparasiticide | |
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Juvenile hormone mimic insecticide | |
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- | |
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- | |
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Synthetic | |
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A juvenile hormone mimic (terpene). Contact and stomach action, acts by mimicing the action of the juvenile hormone keeping the insect in an immature state | |
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- | |
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65733-16-6 | |
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613-834-0 | |
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- | |
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105402 | |
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1711973 | |
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607-725-00-7 | |
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Antiparasitic products, insecticides & repellents: Other ecotparasiticides for topical use | |
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QP53AX28 | |
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No | |
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- | |
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310.48 | |
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- | |
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isopropyl (E,E)-(S)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate | |
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isopropyl (2E,4E, 7S)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate | |
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- | |
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- | |
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Pale yellow liquid | |
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Formulations |
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0.515 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Low | ||||||||
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- | - | - | ||||||||
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100 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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- | - | - | ||||||||
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96 | L3 L = Pesticide manuals and hard copy reference books / other sources (Closed cup)3 = Unverified data of known source |
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1.00 X 1006 | Calculated | - | |||||||
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6.0 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
High | ||||||||
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Soluble | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Regulatory data - observed in metabolism and farm animal feeding studies | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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0.924 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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3.15 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Low volatility. If applied directly to plants or soil, drift is a concern & mitigation is advisable | ||||||||
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0.886 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Moderately volatile | ||||||||
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- |
Degradation |
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10 | B3 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 3 = Unverified data of known source |
Non-persistent | |||||||
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10 | B3 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 3 = Unverified data of known source |
Non-persistent | ||||||||
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1 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Moderately fast | |||||||
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- | ||||||||||
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Stable | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Stable | |||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Slightly mobile | |||||||
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2535 | ||||||||||
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Fate indices |
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0.60 | Calculated | Low leachability | ||||||||||||||||||||||||||
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457 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Edible4 = Verified data |
Threshold for concern | |||||||||||||||||||||||||
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Not available | - |
Known metabolites |
None
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Terrestrial ecotoxicology |
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> 5000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
Low | ||||||||
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- | L2 L = Pesticide manuals and hard copy reference books / other sources Rat 2 yr2 = Unverified data of unknown source |
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5000 | - | |||||||||
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> 2250 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Anas platyrhynchos5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 1000 | C3 C = AGRITOX dataset. Dataset is no longer available. 3 = Unverified data of known source |
Low | ||||||||
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< 2.0 | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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0.76 | L3 L = Pesticide manuals and hard copy reference books / other sources Oncorhynchus mykiss3 = Unverified data of known source |
Moderate | ||||||||
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0.048 | P4 P = Other non-EU, UK or US Governments and Regulators Pimephales promelas 37 day4 = Verified data |
Moderate | ||||||||
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0.36 | L3 L = Pesticide manuals and hard copy reference books / other sources Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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0.051 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna LOEC3 = Unverified data of known source |
Moderate | ||||||||
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0.106 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Americamysis bahia3 = Unverified data of known source |
Moderate | ||||||||
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1.33 | L3 L = Pesticide manuals and hard copy reference books / other sources Scenedesmus subspicatus3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 5000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
Low | ||||||||
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5000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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5.19 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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0.05 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Eliminated in the urine, faeces, and breath with ~70% lost within 5 days | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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No further information available |
Handling issues |
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Not highly flammable up to 263 DegC | |||
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Handling: GHS09 Environment: H410 |
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U (Unlikely to present an acute hazard) | |||
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S-methoprene | ||
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S-metopren | ||
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Record last updated: | 25/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |