Methoprene (Ref: OMS 1697) |
Last updated: 04/02/2024 |
(Also known as: SAN 800; ZR-515) |
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A Juvenile hormone mimic insecticide with antiparasitic activity | |
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Current | |
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1975, registered USA | |
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Used as a flea control on domestic dogs and cats and also as fly control on livestock | |
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Dogs; Cats; Cattle; Horses |
Approval status |
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Not approved as isomer mix | |
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Not approved as isomer mix |
Chemical structure |
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A chiral molecule existing as the R-form (cis) and the S-form (trans). The technical substance is an isomeric mixture but it is the S-form which is more biologically active. | |
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C₁₉H₃₄O₃ | |
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CC(C)OC(=O)C=C(C)C=CCC(C)CCCC(C)(C)OC | |
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CC(C)OC(=O)/C=C(\C)/C=C/CC(C)CCCC(C)(C)OC | |
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NFGXHKASABOEEW-LDRANXPESA-N | |
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InChI=1S/C19H34O3/c1-15(2)22-18(20)14-17(4)11-8-10-16(3)12-9-13-19(5,6)21-7/h8,11,14-16H,9-10,12-13H2,1-7H3/b11-8+,17-14+ | |
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Yes |
General status |
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Insecticide | |
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Juvenile hormone mimic insecticide | |
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Synthetic | |
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Contact and stomach action, acts by mimicing the action of the juvenile hormone keeping the insect in an immature state | |
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- | |
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40596-69-8 | |
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254-993-2 | |
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414 | |
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105401 | |
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5366546 | |
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No data found | |
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Antiparasitic products, insecticides & repellents: Other ecotparasiticides for topical use | |
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QP53AX28 | |
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No | |
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- | |
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310.47 | |
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- | |
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isopropyl (E,E)-(RS)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate | |
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(E,E)-1-methylethyl (2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate | |
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- | |
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- | |
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Yellow to amber coloured liquid | |
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Formulations |
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0.52 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Low | ||||||||
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136 | L3 L = Pesticide manuals and hard copy reference books / other sources (closed cup)3 = Unverified data of known source |
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1.00 X 1005 | Calculated | - | |||||||
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5 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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Soluble | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Regulatory data - observed in metabolism and farm animal feeding studies | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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0.92 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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3.16 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Low volatility. If applied directly to plants or soil, drift is a concern & mitigation is advisable | ||||||||
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0.886 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Moderately volatile | ||||||||
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Degradation |
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10 | B3 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 3 = Unverified data of known source |
Non-persistent | |||||||
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10 | B3 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 3 = Unverified data of known source |
Non-persistent | ||||||||
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1 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Moderately fast | |||||||
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Stable | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Stable | |||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Slightly mobile | |||||||
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2535 | ||||||||||
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Fate indices |
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0.60 | Calculated | Low leachability | ||||||||||||||||||||||||||
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3400 | R4 R = Peer reviewed scientific publications Edible4 = Verified data |
Threshold for concern | |||||||||||||||||||||||||
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Not available | - |
Known soil and groundwater metabolites |
None
Other known metabolites |
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7-methoxycitronellic acid | - | Water (Aerobic) | - |
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Terrestrial ecotoxicology |
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> 34600 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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- | L2 L = Pesticide manuals and hard copy reference books / other sources Rat 2 yr2 = Unverified data of unknown source |
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> 5000 | - | |||||||||
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> 2250 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Anas platyrhynchos5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 1000 | K3 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) Apis mellifera3 = Unverified data of known source |
Low | |||||||
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0.2 | K3 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) Apis mellifera3 = Unverified data of known source |
High | ||||||||
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Aquatic ecotoxicology |
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> 0.76 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Oncorhynchus mykiss5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.089 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Daphnia magna5 = Verified data used for regulatory purposes |
High | ||||||||
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0.051 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna LOEC3 = Unverified data of known source |
Moderate | ||||||||
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0.106 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Americamysis bahia3 = Unverified data of known source |
Moderate | ||||||||
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1.33 | L3 L = Pesticide manuals and hard copy reference books / other sources Scenedesmus subspicatus3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 34600 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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2000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rabbit3 = Unverified data of known source |
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210 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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In cattle it is excreted unchanged in faeces | G3 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 3 = Unverified data of known source |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Health: H315, H335 Environment: H400, H410 |
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U (Unlikely to present an acute hazard) | |||
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methoprene | ||
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méthoprène | ||
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Methoprene | ||
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methopren | ||
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metoprene | ||
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metoprene | ||
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metopren | ||
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Record last updated: | 04/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |