Streptomycin |
Last updated: 24/08/2024 |
(Also known as: streptomycine; streptamine; streptomycin A ; Crop antibiotic) |
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A narrow-spectrum aminoglycoside antibiotic used in veterinary medicine | |
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1944, first reported; 1958, commericalised USA | |
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Used for the management of bacterial infections such as E. coli, Klebsiella spp. and some species of Proteus, Pasteurella and Salmonella | |
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Cattle; Sheep; Horses; Cats; Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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A chiral molecule | |
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C₂₁H₃₉N₇O₁₂ | |
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CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O | |
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C[C@@H]1[C@]([C@@H]([C@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC)(C=O)O | |
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UCSJYZPVAKXKNQ-APUVXCOVSA-N | |
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InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+/m1/s1 | |
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Yes |
General status |
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Antibiotic, Antibacterial, Medicinal drug | |
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Other substance | |
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Micro-organism | |
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Natural | |
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A aminoglycoside that inhibites protein biosynthesis, systemic action | |
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[30S ribosomal protein S12, Antagonist], [16S rRNA, Antagonist] | |
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57-92-1 | |
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200-355-3 | |
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312 | |
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006306 | |
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19649 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01GA01 | |
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No | |
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Allowed substance (Table 1: Ruminants, Porcine, Rabbits) | |
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581.57 | |
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O-2-deoxy-2-methylamino-α-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1-4)-N1,N3-diamidino-D-streptamine | |
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O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-D-streptamine | |
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White powder | |
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Formulations |
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Usually formulated as a suspension for intramammary injection in combination with other medicinal drugs |
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1000000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
High | ||||||||
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12 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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3.16 X 10-08 | Calculated | - | |||||||
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-7.5 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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n/a | - | - | ||||||||
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7.76 X 10-23 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
Low volatility | ||||||||
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8.52 X 10-39 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
Non-volatile | ||||||||
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Degradation |
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1.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-persistent | ||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Moderately mobile | |||||||
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339 | ||||||||||
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Fate indices |
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0.00 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 9000 | G3 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) Rat3 = Unverified data of known source |
Low | ||||||||
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> 4640 | E4 E = Manufacturers safety data sheets Anas platyrhynchos4 = Verified data |
Low | ||||||||
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Aquatic ecotoxicology |
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> 180 | E4 E = Manufacturers safety data sheets Oncorhynchus mykiss4 = Verified data |
Low | ||||||||
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487 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Low | ||||||||
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0.133 | R4 R = Peer reviewed scientific publications Pseudokirchneriella subcapitata4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 9000 | G3 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) Rat3 = Unverified data of known source |
Low | ||||||||
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325 | L3 L = Pesticide manuals and hard copy reference books / other sources Mouse3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 525 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LDLo = 175 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Majority of oral dose is excreted in the faeces. Parenteral administration leads to urinal elimination. | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Health issues |
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May cause rashes, hives, headache, drop in blood pressure, nausea and vomiting Possible kidney toxicant May cause hearing dysfunction |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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streptomycin | ||
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streptomycine | ||
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Streptomyzin | ||
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streptomicina | ||
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estreptomicina | ||
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Record last updated: | 24/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |