Sulfadiazine |
Last updated: 02/05/2024 |
(Also known as: adiazine; diazolone; SDZ; SDA; sulfanilamidopyrimidine; sulfapyrimidine) |
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A commonly used synthetically produced livestock antibiotic / antimicrobial with antiparasitic properties | |
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Current | |
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circa 1935, discovered | |
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Multiple uses including bladder and prostate infections, Nocardia infections, or parasitic infections | |
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Dogs; Cats; Horses, Cattle; Poultry; Pigs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₀H₁₀N₄O₂S | |
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C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N | |
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- | |
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SEEPANYCNGTZFQ-UHFFFAOYSA-N | |
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InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14) | |
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Yes |
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Common Name | Relationship | Link |
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sulfadiazine | - |
General status |
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Antiparasitic, Antibacterial, Coccidiostat, Antiprotozoal | |
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Sulfonamide substance | |
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Synthetic | |
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Inhibits the production of folic acid necessary for the growth and multiplication of bacteria | |
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[Dihydropteroate synthetase, Antagonist] | |
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68-35-9 | |
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200-685-8 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01EW10 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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250.278 | |
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- | |
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4-amino-N-pyrimidin- 2-yl-benzenesulfonamide | |
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4-amino-N-2-pyrimidinylbenzenesulfonamide | |
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Potential groundwater pollutant | |
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White to slightly yellow crystalline powder | |
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Formulations |
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Bimamix Oral Suspension | Bimeda Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Diatrim Solution for Injection | Eurovet Animal health B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Equibactin Vet Oral Paste | Le Vet B.V. | GB National authorisation (IC) | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Trimesoxine Tablets | Vetoquinol UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Formulated in a variety of different products including medicated feeds, oral pastes, solutions for injection and oral suspensions |
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130 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Moderate | ||||||||
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252 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Decomposes before boiling | R4 R = Peer reviewed scientific publications 4 = Verified data |
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8.13 X 10-01 | Calculated | - | |||||||
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-0.09 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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2.49 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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pKa(2) = 6.48 | |||||||||||
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5.73 X 10-03 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Substance may enter the environment via the urine and faeces of treated animals or by leaching from spilt medicated feed. Monitoring studies have identified this substance in pig, cattle and poultry manure. |
Degradation |
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17 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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Stable | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Stable | |||||||
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5.5 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Fast | ||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately mobile | |||||||
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81 | ||||||||||
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General literature states Koc range 37-125 mL g⁻¹ | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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N4-acetyl-sulfadiazine | Ac-SDZ | Animals (Urine) | - |
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Terrestrial ecotoxicology |
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1500 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 57 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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7.8 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
Moderate | ||||||||
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< 1.00 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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1500 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
Moderate | ||||||||
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Intraperitoneal LD₅₀ = 750 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ = 880 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Largely excreted in the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible kidney and renal system toxicant |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Not listed (Not listed) | |||
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Packaging Group III (minor danger) | |||
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sulfadiazine | ||
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sulfadiazine | ||
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Sulfapyrimidin | ||
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sulfadiazina | ||
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Record last updated: | 02/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |